Evidence map›Paper›PMID 27733935›Full record

ArticleBJPsych open2016

Effectiveness of antipsychotics used in first-episode psychosis: a naturalistic cohort study.

Richard Whale, Michael Harris, Gail Kavanagh, Vijitha Wickramasinghe, Christopher I Jones, Steven Marwaha, Ketan Jethwa, Nirmalan Ayadurai, Andrew Thompson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJPsych open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Illness Phase as a Key Assessment and Intervention Window for Psychosis.Biological psychiatry global open science · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Richard Whale, MD, MRCPsych, Sussex Partnership NHS Foundation Trust, Brighton, UK, and Brighton and Sussex Medical School, Brighton, UK.
Michael Harris, MSc, MRCPsych, Sussex Partnership NHS Foundation Trust, Brighton, UK.
Gail Kavanagh, MRCPsych, Sussex Partnership NHS Foundation Trust, Brighton, UK.
Vijitha Wickramasinghe, MSc, MBBS, Sussex Partnership NHS Foundation Trust, Eastbourne, UK.
Christopher I Jones, PhD, Brighton and Sussex Medical School, Brighton, UK.
Steven Marwaha, PhD, MRCPsych, Division of Mental Health and Wellbeing, University of Warwick, Coventry, UK, and Coventry and Warwickshire Partnership NHS Trust, Coventry, UK.
Ketan Jethwa, PGCert, BMBS, Division of Mental Health and Wellbeing, University of Warwick, Coventry, UK, and Coventry and Warwickshire Partnership NHS Trust, Coventry, UK.
Nirmalan Ayadurai, MRCPsych, Coventry and Warwickshire Partnership NHS Trust, Coventry, UK.
Andrew Thompson, MD, FRCPsych, Division of Mental Health and Wellbeing, University of Warwick, Coventry, UK, and Coventry and Warwickshire Partnership NHS Trust, Coventry, UK.
Coventry and Warwickshire Partnership NHS Trust · GBSussex Partnership NHS Foundation Trust · GBBrighton and Sussex Medical School · GBUniversity of Warwick · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOne year of antipsychotic treatment from symptom remission is recommended following a first episode of psychosis (FEP).

aimsTo investigate the effectiveness of commonly used antipsychotic medications in FEP.

methodA retrospective cohort study of naturalistic treatment of patients (

resultsRisk of treatment discontinuation is greatest within 3 months of treatment initiation. Risperidone had longest median survival time. No significant differences were observed in time to discontinuation between commonly used antipsychotics on multivariable Cox regression analysis. Poor adherence and efficacy failure were the most common reasons for discontinuation.

conclusionsEffectiveness differences appear not to be a current reason for antipsychotic choice in FEP. Adherence strategies and weighing up likely adverse effects should be the clinical focus. DECLARATION OF INTEREST: R.W., A.T. and S.M. have received research grant, speaker honoraria and conference attendance funding from all companies marketing antipsychotics. COPYRIGHT AND USAGE: © The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license.

Identifiers

PMID27733935
PMCPMC5056529
OpenAlexW2531546259

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.