ArticleFrontiers in aging neuroscience2016
A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers.
Article in Frontiers in aging neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Trial
- Effect of increasing cognitive activity participation via calligraphy practice on salient network and central executive network in older adults with subjective cognitive decline: a secondary analysis of a randomized controlled trial.Frontiers in aging neuroscience · 2026Article
- Early detection of dementia with default-mode network effective connectivity.Nature. Mental health · 2024Article
- Dysregulated Salience Network Control over Default-Mode and Central-Executive Networks in Schizophrenia Revealed Using Stochastic Dynamical Causal Modeling.Brain connectivity · 2024Article
- Transcranial direct current stimulation and neuronal functional connectivity in MCI: role of individual factors associated to AD.Frontiers in psychiatry · 2024Article
- Effects of non-modifiable risk factors of Alzheimer's disease on intracortical myelin content.Alzheimer's research & therapy · 2022Article
- Evaluation of in vivo staging of amyloid deposition in cognitively unimpaired elderly aged 78-94.Molecular psychiatry · 2022Article
- Changes in Brain Functional and Effective Connectivity After Treatment for Breast Cancer and Implications for Intervention Targets.Brain connectivity · 2022Article
- The Effect of APOE ɛ4 on the Functional Connectivity in Frontoparietal Network in Hypertensive Patients.Brain sciences · 2022Article
- A Triple-Network Dynamic Connection Study in Alzheimer's Disease.Frontiers in psychiatry · 2022Article
- Impact ofFrontiers in aging neuroscience · 2022Article
- Genetic association of apolipoprotein E genotype with EEG alpha rhythm slowing and functional brain network alterations during normal aging.Frontiers in neuroscience · 2022Article
- Differences in resting state functional connectivity underlie visuomotor performance declines in older adults with a genetic risk (Frontiers in aging neuroscience · 2022Article
- Interactive effects of the APOE and BDNF polymorphisms on functional brain connectivity: the Tasmanian Healthy Brain Project.Scientific reports · 2021Article
- Resting-state networks in the course of aging-differential insights from studies across the lifespan vs. amongst the old.Pflugers Archiv : European journal of physiology · 2021Review
- Dynamic neural circuit disruptions associated with antisocial behaviors.Human brain mapping · 2021Article
- Disrupted Dynamic Functional Connectivity in Distinguishing Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment Based on the Triple-Network Model.Frontiers in aging neuroscience · 2021Article
- Brain Functional Interaction of Acupuncture Effects in Diarrhea-Dominant Irritable Bowel Syndrome.Frontiers in neuroscience · 2020Article
- The superior longitudinal fasciculus and its functional triple-network mechanisms in brooding.NeuroImage. Clinical · 2019Article
- The Influence of Genetic Factors and Cognitive Reserve on Structural and Functional Resting-State Brain Networks in Aging and Alzheimer's Disease.Frontiers in aging neuroscience · 2019Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
The triple network model, consisting of the central executive network (CEN), salience network (SN) and default mode network (DMN), has been recently employed to understand dysfunction in core networks across various disorders. Here we used the triple network model to investigate the large-scale brain networks in cognitively normal apolipoprotein e4 (APOE4) carriers who are at risk of Alzheimer's disease (AD). To explore the functional connectivity for each of the three networks and the effective connectivity among them, we evaluated 17 cognitively normal individuals with a family history of AD and at least one copy of the APOE4 allele and compared the findings to those of 12 individuals who did not carry the APOE4 gene or have a family history of AD, using independent component analysis (ICA) and Bayesian network (BN) approach. Our findings indicated altered within-network connectivity that suggests future cognitive decline risk, and preserved between-network connectivity that may support their current preserved cognition in the cognitively normal APOE4 allele carriers. The study provides novel sights into our understanding of the risk factors for AD and their influence on the triple network model of major psychopathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.