Evidence map›Paper›PMID 27733776›Full record

ArticleLeukemia2017

Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation cascades.

M Adamiak, A Abdelbaset-Ismail, M Suszynska, A Abdel-Latif, J Ratajczak, M Z Ratajczak

Abstract read
In one paragraph

Article in Leukemia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Review
  3. The Role of NLRP3, a Star of Excellence in Myeloproliferative Neoplasms.International journal of molecular sciences · 2023
    Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

M AdamiakStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
A Abdelbaset-IsmailStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
M SuszynskaStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
A Abdel-LatifDivision of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY, USA.
J RatajczakStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
M Z RatajczakStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.

Funding

The role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI REN, HONGMEI · 2012 to 2017
$13.7M
Novel mechanisms involving complement cascade in stem cell traffickingR01DK074720 · NIDDK · UNIVERSITY OF LOUISVILLE · PI RATAJCZAK, MARIUSZ Z · 2007 to 2020
$4.1M
BIOACTIVE LIPIDS IN STEM CELL HOMING AND MOBILIZATIONR01HL112788 · NHLBI · UNIVERSITY OF LOUISVILLE · PI RATAJCZAK, MARIUSZ Z · 2013 to 2016
$1.5M
NHLBI NIH HHS R01 HL112788NIDDK NIH HHS R01 DK074720NIGMS NIH HHS P20 GM103527
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Hematopoietic Stem Cell MobilizationAnimalsBlood CoagulationComplement ActivationMannose-Binding LectinMannose-Binding Protein-Associated Serine ProteasesMice, KnockoutMannose-Binding LectinMannose-Binding Protein-Associated Serine ProteasesMASP-1 protein, mouse

Identifiers

PMID27733776
PMCPMC5214582

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.