ArticleJournal of clinical microbiology2016
Optimal Length of Cultivation Time for Isolation of Propionibacterium acnes in Suspected Bone and Joint Infections Is More than 7 Days.
Article in Journal of clinical microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.
- Best microbiological practice recommendations for the diagnosis of peri-prosthetic joint infections: the CRIOGO bacteriology reference center network.Annals of clinical microbiology and antimicrobials · 2025Pooled it
- Article
- Data from the Swiss National Arthroplasty Registry SIRIS suggest that unicompartmental knee arthroplasty is associated with a lower risk of periprosthetic joint infection than total knee arthroplasty.Archives of orthopaedic and trauma surgery · 2026Article
- Diagnostic value of preoperative joint aspiration for periprosthetic shoulder infection: analysis of microbiological aspects and preoperative ICM minor criteria.Archives of orthopaedic and trauma surgery · 2025Article
- Innovative fast and low-cost method for the detection of living bacteria based on trajectory.Scientific reports · 2025Article
- Prolonged incubation time unwarranted for acute periprosthetic joint infections.Journal of clinical microbiology · 2025Article
- Systemic antibiotic prophylaxis in arthroplasty - a narrative review of how many doses are optimal.EFORT open reviews · 2024Review
- Photodynamic therapy forShoulder & elbow · 2024Article
- Can pre-analytical procedures improve microbiological culture yield in patients with periprosthetic infections?BMC microbiology · 2024Article
- A Literature Review of Cutibacterium Acnes: From Skin Commensal to Pathogen in Shoulder Surgery.Cureus · 2024Review
- Quantitative Real-Time Polymerase Chain Reaction May Serve as a Useful Adjunct to Conventional Culture in The Detection of Cutibacterium acnes in the Glenohumeral Joint: A Study of 100 Consecutive Patients.The archives of bone and joint surgery · 2024Article
- Comparative Genomic Analysis ofMicroorganisms · 2023Article
- Treatment outcomes of patients with Cutibacterium acnes-positive cultures during total joint replacement revision surgery: a minimum 2-year follow-up.Archives of orthopaedic and trauma surgery · 2023Article
- Article
- Shotgun sequencing of sonication fluid for the diagnosis of orthopaedic implant-associated infections withFrontiers in cellular and infection microbiology · 2023Article
- Antibiotic Stewardship in Treatment of Osteoarticular Infections Based on Local Epidemiology and Bacterial Growth Times.Microbiology spectrum · 2022Article
- Microbiological Characterization ofAntibiotics (Basel, Switzerland) · 2022Article
- True infection or contamination in patients with positive Cutibacterium blood cultures-a retrospective cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022Article
- Pseudoseptic Arthritis in a Patient With Psoriasis.Cureus · 2021Article
- Cultivation of common bacterial species and strains from human skin, oral, and gut microbiota.BMC microbiology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diagnosis of Propionibacterium acnes bone and joint infection is challenging due to the long cultivation time of up to 14 days. We retrospectively studied whether reducing the cultivation time to 7 days allows accurate diagnosis without losing sensitivity. We identified patients with at least one positive P. acnes sample between 2005 and 2015 and grouped them into "infection" and "no infection." An infection was defined when at least two samples from the same case were positive. Clinical and microbiological data, including time to positivity for different cultivation methods, were recorded. We found 70 cases of proven P. acnes infection with a significant faster median time to positivity of 6 days (range, 2 to 11 days) compared to 9 days in 47 cases with P. acnes identified as a contamination (P < 0.0001). In 15 of 70 (21.4%) patients with an infection, tissue samples were positive after day 7 and in 6 patients (8.6%) after day 10 when a blind subculture of the thioglycolate broth was performed. The highest sensitivity was detected for thioglycolate broth (66.3%) and the best positive predictive values for anaerobic agar plates (96.5%). A prolonged transportation time from the operating theater to the microbiological laboratory did not influence time to positivity of P. acnes growth. By reducing the cultivation time to 7 days, false-negative diagnoses would increase by 21.4%; thus, we recommend that biopsy specimens from bone and joint infections be cultivated to detect P. acnes for 10 days with a blind subculture at the end.
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