Evidence map›Paper›PMID 27733612›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016

Sustained Gq-Protein Signaling Disrupts Striatal Circuits via JNK.

Luigi Bellocchio, Andrea Ruiz-Calvo, Anna Chiarlone, Magali Cabanas, Eva Resel, Jean-René Cazalets, Cristina Blázquez, Yoon H Cho, Ismael Galve-Roperh, Manuel Guzmán

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Lack of adipocyte purinergic P2YProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  2. Article
  3. Gene therapy approaches in the non-human primate model of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2018
    Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Luigi BellocchioDepartment of Biochemistry and Molecular Biology I, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), and Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, 28040 Madrid, Spain, and mguzman@quim.ucm.es luigi.bellocchio@inserm.fr.ORCID 0000-0001-7774-3935
Andrea Ruiz-CalvoDepartment of Biochemistry and Molecular Biology I, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), and Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, 28040 Madrid, Spain, and.
Anna ChiarloneDepartment of Biochemistry and Molecular Biology I, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), and Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, 28040 Madrid, Spain, and.
Magali CabanasInstitute of Cognitive and Integrative Neuroscience of Aquitaine, University of Bordeaux, 33615 Pessac Cedex, France.
Eva ReselDepartment of Biochemistry and Molecular Biology I, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), and Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, 28040 Madrid, Spain, and.
Jean-René CazaletsInstitute of Cognitive and Integrative Neuroscience of Aquitaine, University of Bordeaux, 33615 Pessac Cedex, France.
Cristina BlázquezDepartment of Biochemistry and Molecular Biology I, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), and Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, 28040 Madrid, Spain, and.
Yoon H ChoInstitute of Cognitive and Integrative Neuroscience of Aquitaine, University of Bordeaux, 33615 Pessac Cedex, France.
Ismael Galve-RoperhDepartment of Biochemistry and Molecular Biology I, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), and Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, 28040 Madrid, Spain, and.ORCID 0000-0003-3501-2434
Manuel GuzmánDepartment of Biochemistry and Molecular Biology I, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), and Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, 28040 Madrid, Spain, and mguzman@quim.ucm.es luigi.bellocchio@inserm.fr.
Biomedical Research Networking Center on Neurodegenerative Diseases · ESUniversité de Bordeaux · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dorsal striatum is a major input structure of the basal ganglia and plays a key role in the control of vital processes such as motor behavior, cognition, and motivation. The functionality of striatal neurons is tightly controlled by various metabotropic receptors. Whereas the G SIGNIFICANCE STATEMENT: The dorsal striatum is a major input structure of the basal ganglia and plays a key role in the control of vital processes such as motor behavior, cognition, and motivation. Whereas the G

Indexed as

AnimalsBehavior, AnimalCalcium SignalingElectroencephalographyGTP-Binding Protein alpha Subunits, Gq-G11JNK Mitogen-Activated Protein KinasesMaleMiceMice, Inbred C57BLNeostriatumNeural PathwaysPsychomotor PerformanceSignal TransductionSpace PerceptionType C PhospholipasesGTP-Binding Protein alpha Subunits, Gq-G11JNK Mitogen-Activated Protein KinasesType C PhospholipasescJun N-terminal kinaseG-protein-coupled receptormedium spiny neuronstriatal circuit

Identifiers

PMID27733612
PMCPMC6601931
OpenAlexW2530788826

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.