ArticleNeurology2016
Slow gait, white matter characteristics, and prior 10-year interleukin-6 levels in older adults.
Article in Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Inflammatory Biomarkers and Gait Impairment in Older Adults: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Gait and falls in cerebral small vessel disease: a systematic review and meta-analysis.Age and ageing · 2023Pooled it
- Interleukin-6 is associated with white matter hyperintensities and cognition independent of Alzheimer's disease plasma biomarkers-HABS-HD.Journal of Alzheimer's disease : JAD · 2026Article
- Associations of mid-to-late-life inflammation with late-life mobility and the influences of chronic comorbidities, race, and social determinants of health: The Atherosclerosis Risk in Communities Study.Journal of the American Geriatrics Society · 2024Article
- Correlates of Gait Speed Among Older Adults From 6 Countries: Findings From the COSMIC Collaboration.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Are falls a manifestation of brain failure? Revisited 40 years later.Age and ageing · 2023Article
- The Correlation Between Modified Total Cerebral Small Vessel Disease Score and Gait and Balance Disorder in Middle-aged to Older Adults.Current neurovascular research · 2022Article
- Relationships of inflammation trajectories with white matter volume and integrity in midlife.Brain, behavior, and immunity · 2021Article
- Association of Neurocognitive and Physical Function With Gait Speed in Midlife.JAMA network open · 2019Article
- A population neuroscience approach to the study of cerebral small vessel disease in midlife and late life: an invited review.American journal of physiology. Heart and circulatory physiology · 2018Review
- Systemic Inflammation Mediates Age-Related Cognitive Deficits.Frontiers in aging neuroscience · 2018Article
- Advanced Neuroimaging of Cerebral Small Vessel Disease.Current treatment options in cardiovascular medicine · 2017Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo examine the relationship between gait speed and prior 10 years interleukin-6 (IL-6) burden in older adults. We then assessed whether white matter characteristics influence this relationship.
methodsIn 179 community-dwelling older adults, gait speed was assessed on an automated walkway and serum IL-6 was assayed on ELISA. Concurrently, white matter characteristics were assessed on MRI by quantifying volume of white matter hyperintensities (WMH), a marker of small vessel disease, and normal-appearing white matter on fractional anisotropy (NAWM-FA), a marker of axonal integrity. IL-6 was assayed at regular intervals at gait assessment and over the prior 10 years and estimates of sustained 10-year IL-6 exposure and the rate of change in IL-6 over 10 years were obtained. Multivariate linear regressions were used to examine the relationships among sustained IL-6 exposure, rate of change in IL-6, gait speed, and white matter characteristics.
resultsIn this sample (age 83 years, 58% female, 41% black, gait speed 0.9 m/s), higher sustained IL-6 levels, but not the rate of change in IL-6 or IL-6 at gait assessment, was significantly related to slower gait (β = -0.27, p < 0.001) and to higher WMH (β = 0.23, p = 0.002), but not NAWM-FA, withstanding covariate adjustments. WMH accounted for 30% attenuation in the relationship between higher sustained IL-6 levels and slower gait speed (p = 0.043) in the mediation analyses.
conclusionsSustained exposure to high IL-6 over 10 years rather than the rate of change in IL-6 or an isolated high IL-6 level may adversely affect gait speed by influencing cerebral WMH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.