ArticleProceedings. Biological sciences2016
Marker-dependent associations among oxidative stress, growth and survival during early life in a wild mammal.
Article in Proceedings. Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 45 citations in OpenAlex.
- Enhancing Sheep Rumen Function, and Growth Performance Through Yeast Culture and Oxalic Acid Supplementation in a Hemicellulose-Based Diet.Microorganisms · 2025Article
- Growth rate is associated with reduced oxidative stress and this effect is modulated by the degree of social dominance in males of an African cichlid fish.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2025Article
- Early Oxidative Stress May Prevent a Red Ornament From Signaling Longevity.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2025Article
- Methodological confounds of measuring urinary oxidative stress in wild animals.Ecology and evolution · 2022Article
- How much energetic trade-offs limit selection? Insights from livestock and related laboratory model species.Evolutionary applications · 2021Article
- A genetics-based approach confirms immune associations with life history across multiple populations of an aquatic vertebrate (Gasterosteus aculeatus).Molecular ecology · 2018Article
- Development of small blood volume assays for the measurement of oxidative stress markers in mammals.PloS one · 2018Article
- Marker-dependent associations among oxidative stress, growth and survival during early life in a wild mammal.Proceedings. Biological sciences · 2016Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Oxidative stress (OS) is hypothesized to be a key physiological mechanism mediating life-history trade-offs, but evidence from wild populations experiencing natural environmental variation is limited. We tested the hypotheses that increased early life growth rate increases OS, and that increased OS reduces first-winter survival, in wild Soay sheep (Ovis aries) lambs. We measured growth rate and first-winter survival for four consecutive cohorts, and measured two markers of oxidative damage (malondialdehyde (MDA), protein carbonyls (PC)) and two markers of antioxidant (AOX) protection (total AOX capacity (TAC), superoxide dismutase (SOD)) from blood samples. Faster lamb growth was weakly associated with increased MDA, but not associated with variation in the other three markers. Lambs with higher SOD activity were more likely to survive their first winter, as were male but not female lambs with lower PC concentrations. Survival did not vary with MDA or total TAC. Key predictions relating OS to growth and survival were therefore supported in some OS markers, but not others. This suggests that different markers capture different aspects of the complex relationships between individual oxidative state, physiology and fitness, and that overarching hypotheses relating OS to life-history variation cannot be supported or refuted by studying individual markers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.