Observational studyThe journals of gerontology. Series A, Biological sciences and medical sciences2017
Cardiovascular Dysfunction and Frailty Among Older Adults in the Community: The ARIC Study.
Observational study in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 5 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- A systematic review of the relationship between body composition including muscle, fat, bone, and body water and frailty in Asian residents.Nagoya journal of medical science · 2025Pooled it
- Frailty Syndromes in Persons With Cerebrovascular Disease: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2019Pooled it
- Pooled it
- Observational Evidence for Unintentional Weight Loss in All-Cause Mortality and Major Cardiovascular Events: A Systematic Review and Meta-Analysis.Scientific reports · 2018Pooled it
- The Relationship between Anaemia and Frailty: A Systematic Review and Meta-Analysis of Observational Studies.The journal of nutrition, health & aging · 2018Pooled it
- Trial
- Identifying Frail-Related Biomarkers among Community-Dwelling Older Adults in Japan: A Research Example from the Japanese Gerontological Evaluation Study.BioMed research international · 2018Trial
- The frailty mortality link in people with chronic diseases pertaining to 13 body organ systems: findings from the UK Biobank study.GeroScience · 2026Article
- Frailty and Echocardiographic Indices of Diastolic Function in Older Adults: A Cross-Sectional Analysis.Journal of clinical medicine · 2026Article
- Recurrence or persistence of atrial fibrillation is associated with frailty and adverse outcomes: the SAGE-AF cohort study.BMC geriatrics · 2026Article
- The predictive value of the hospital frailty risk score for 28-day mortality in older critically ill patients with acute ischemic stroke.BMC geriatrics · 2026Article
- The Impact of Frailty on Left Ventricle Mass and Geometry in Elderly Patients with Normal Ejection Fraction: A STROBE-Compliant Cross-Sectional Study.Journal of cardiovascular development and disease · 2026Article
- The Biological Mechanisms of Frailty: Focusing on Cellular Senescence.European cardiology · 2026Review
- Untangling the prognostic value of diastolic dysfunction, NT-proBNP, and frailty in older patients with preserved left ventricular ejection fraction without valvular disease.BMC geriatrics · 2025Observational
- Brazilian Guidelines of Hypertension - 2025.Arquivos brasileiros de cardiologia · 2025Article
- Research Progress on the Biological Activities and Clinical Applications of Pseudoprotodioscin.Current issues in molecular biology · 2025Review
- Poor olfaction and risk of heart failure in the Atherosclerosis Risk in Communities Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Association between frailty and echocardiographic findings in hospitalized older adults with preserved ejection fraction.European heart journal open · 2025Article
- Splenic and portal venous flow associated with frailty and sarcopenia in older outpatients with cardiovascular disease.BMC geriatrics · 2025Article
- Cardio-Oncology Challenges in Elderly Patients.Journal of clinical medicine · 2025Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe contribution of cardiovascular dysfunction to frailty in older adults is uncertain. This study aimed to define the relationship between frailty and cardiovascular structure and function, and determine whether these associations are independent of coexisting abnormalities in other organ systems.
methodsWe studied 3,991 older adults (mean age 75.6±5.0 years; 59% female) from the Atherosclerosis Risk in Communities (ARIC) Study in whom the following six organ systems were uniformly assessed: cardiac (by echocardiography), vascular (by ankle-brachial-index and pulse-wave-velocity), pulmonary (by spirometry), renal (by estimated glomerular filtration rate), hematologic (by hemoglobin), and adipose (by body mass index and bioimpedance). Frailty was defined by the presence of ≥3 of the following: low strength, low energy, slowed motor performance, low physical activity, or unintentional weight loss.
resultsTwo hundred eleven (5.3%) participants were frail. In multivariable analyses adjusted for demographics, diabetes, hypertension, and measures of other organ system function, frailty was independently and additively associated with left ventricular hypertrophy (odds ratio [OR] = 1.72; 95% confidence interval [CI] = 1.30-2.40), reduced global longitudinal strain (reflecting systolic function; OR = 1.68; 95% CI = 1.16-2.44), and greater left atrial volume index (reflecting diastolic function; OR = 1.60; 95% CI = 1.13-2.27), which together demonstrated the greatest association with frailty (OR = 2.10; 95% CI = 1.57-2.82) of the systems studied. Lower magnitude associations were observed for vascular and pulmonary abnormalities, anemia, and impaired renal function. Cardiovascular abnormalities remained associated with frailty after excluding participants with prevalent cardiovascular disease.
conclusionsAbnormalities of cardiac structure and function are independently associated with frailty, and together show the greatest association with frailty among the organ systems studied.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.