ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2016
Intestinal inflammation without weight loss decreases bone density and growth.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Cross-talk of gut-bone-muscle: osteosarcopenia in experimental colitis models.Laboratory animal research · 2026Review
- Article
- Combination of Cinnamaldehyde with Carvacrol or Thymol Improves the Mechanical Properties of Tibia in Post-Peak Laying Hens.Animals : an open access journal from MDPI · 2022Article
- A novel gut inflammatory rat model by laparotomic injection of peptidoglycan from Staphylococcus aureus.Archives of microbiology · 2022Article
- Acidification of drinking water improved tibia mass of broilers through the alterations of intestinal barrier and microbiota.Animal bioscience · 2022Article
- Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss.World journal of gastroenterology · 2022Article
- Bone Alterations in Inflammatory Bowel Diseases: Role of Osteoprotegerin.Journal of clinical medicine · 2022Article
- Intestinal Inflammation Promotes MDL-1Cellular and molecular gastroenterology and hepatology · 2022Article
- 25-hydroxycholecalciferol reverses heat induced alterations in bone quality in finisher broilers associated with effects on intestinal integrity and inflammation.Journal of animal science and biotechnology · 2021Article
- Mechanisms Underlying Bone Loss Associated with Gut Inflammation.International journal of molecular sciences · 2019Review
- Probiotic Lactobacillus reuteri Prevents Postantibiotic Bone Loss by Reducing Intestinal Dysbiosis and Preventing Barrier Disruption.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- Gut-derived serotonin contributes to bone deficits in colitis.Pharmacological research · 2019Article
- The effects of dihydroartemisinin on inflammatory bowel disease-related bone loss in a rat model.Experimental biology and medicine (Maywood, N.J.) · 2018Article
- Advances in Probiotic Regulation of Bone and Mineral Metabolism.Calcified tissue international · 2018Review
- High Molecular Weight Polymer Promotes Bone Health and Prevents Bone Loss UnderFrontiers in physiology · 2018Article
- Inflammatory Diseases and Growth: Effects on the GH-IGF Axis and on Growth Plate.International journal of molecular sciences · 2017Review
- Epithelial Barrier Function in Gut-Bone Signaling.Advances in experimental medicine and biology · 2017Review
- Probiotics in Gut-Bone Signaling.Advances in experimental medicine and biology · 2017Review
- Immunology of Gut-Bone Signaling.Advances in experimental medicine and biology · 2017Article
- Lactobacillus reuteri 6475 Increases Bone Density in Intact Females Only under an Inflammatory Setting.PloS one · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Increasing evidence indicates a strong link between intestinal health and bone health. For example, inflammatory bowel disease can cause systemic inflammation, weight loss, and extra-intestinal manifestations, such as decreased bone growth and density. However, the effects of moderate intestinal inflammation without weight loss on bone health have never been directly examined; yet this condition is relevant not only to IBD but to conditions of increased intestinal permeability and inflammation, as seen with ingestion of high-fat diets, intestinal dysbiosis, irritable bowel syndrome, metabolic syndrome, and food allergies. Here, we induced moderate intestinal inflammation without weight loss in young male mice by treating with a low dose of dextran sodium sulfate (1%) for 15 days. The mice displayed systemic changes marked by significant bone loss and a redistribution of fat from subcutaneous to visceral fat pad stores. Bone loss was caused by reduced osteoblast activity, characterized by decreased expression of osteoblast markers (runx2, osteocalcin), histomorphometry, and dynamic measures of bone formation. In addition, we observed a reduction in growth plate thickness and hypertrophic chondrocyte matrix components (collagen X). Correlation analyses indicate a link between gut inflammation and disease score, but more importantly, we observed that bone density measures negatively correlated with intestinal disease score, as well as colon and bone TNF-α levels. These studies demonstrate that colitis-induced bone loss is not dependent upon weight loss and support a role for inflammation in the link between gut and bone health, an important area for future therapeutic development.
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