Evidence map›Paper›PMID 27733365›Full record

ArticleAmerican journal of physiology. Cell physiology2016

Transcriptional regulation of importin-α1 by JunD modulates subcellular localization of RNA-binding protein HuR in intestinal epithelial cells.

Yan Xu, Jie Chen, Lan Xiao, Hee Kyoung Chung, Yuan Zhang, Joseph C Robinson, Jaladanki N Rao, Jian-Ying Wang

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yan XuCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Jie ChenCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Lan XiaoCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Hee Kyoung ChungCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Yuan ZhangCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Joseph C RobinsonCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Jaladanki N RaoCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Jian-Ying WangCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland; jywang@som.umaryland.edu.
University of Maryland, Baltimore · US

Funding

Surgical Studies of Gut PermeabilityR01DK068491 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI Jian-Ying Wang · 2004 to 2026
$7.0M
Mucosal Repair in Gut Surgical DisordersR01DK061972 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI WANG, JIAN-YING · 2002 to 2023
$6.7M
REGULATION OF INTESTINAL EPITHELIAL RESTITUTIONI01BX000332 · VA · BALTIMORE VA MEDICAL CENTER · PI Jian-Ying Wang · 2009 to 2026
–
SURGICAL STUDIES ON MUCOSAL HOMEOSTASISI01BX000713 · VA · BALTIMORE VA MEDICAL CENTER · PI WANG, JIAN-YING · 2011 to 2024
–
BLRD VA I01 BX000332BLRD VA I01 BX000713NIDDK NIH HHS R01 DK061972NIDDK NIH HHS R01 DK068491
6 · The paper itself

Abstract

The RNA-binding protein HuR is crucial for normal intestinal mucosal regeneration by modulating the stability and translation of target mRNAs, but the exact mechanism underlying HuR trafficking between the cytoplasm and nucleus remains largely unknown. Here we report a novel function of transcription factor JunD in the regulation of HuR subcellular localization through the control of importin-α

Indexed as

alpha KaryopherinsAnimalsApoptosisBinding SitesCaco-2 CellsCell LineCell Line, TumorCytoplasmELAV-Like Protein 1Epithelial CellsEpitheliumGene Expression RegulationHumansIntestinal MucosaPolyaminesPromoter Regions, Geneticalpha KaryopherinsELAV-Like Protein 1PolyaminesProto-Oncogene Proteins c-junRNA-Binding ProteinsRNA, Messengerapoptosisintestinal epithelial cellsnuclear pore complexsubcellular trafficking

Identifiers

PMID27733365
PMCPMC5206309
OpenAlexW2530747332

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.