ArticleJournal of the American Heart Association2016
Changes in Medical Therapy and Lifestyle After Anatomical or Functional Testing for Coronary Artery Disease.
Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01174550 (PROspective Multicenter Imaging Study for Evaluation of Chest Pain - The PROMISE Trial), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PROspective Multicenter Imaging Study for Evaluation of Chest Pain - The PROMISE Trial
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison of mid- to long-term clinical outcomes between anatomical testing and usual care in patients with suspected coronary artery disease: A meta-analysis of randomized trials.Clinical cardiology · 2017Pooled it
- Survival After Initial Stress Testing vs Anatomic Testing in Suspected Coronary Artery Disease: Long-Term Follow-Up of the PROMISE Randomized Clinical Trial.JAMA cardiology · 2025Trial
- Cost-effectiveness Analysis of Anatomic vs Functional Index Testing in Patients With Low-Risk Stable Chest Pain.JAMA network open · 2020Trial
- Prognostic Value of Coronary Artery Calcium in the PROMISE Study (Prospective Multicenter Imaging Study for Evaluation of Chest Pain).Circulation · 2017Trial
- Real-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort study.European heart journal. Digital health · 2024Article
- Reframing the Paradigm for Assessing Optimal Test Selection When Suspecting Chronic Coronary Disease.Journal of the American Heart Association · 2023Article
- Prognostic value of CT-derived coronary artery disease characteristics varies by ASCVD risk: insights from the PROMISE trial.European radiology · 2023Article
- Development and validation of ischemia risk scores.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Diagnostic and Therapeutic Strategies for Stable Coronary Artery Disease Following the ISCHEMIA Trial.JACC. Asia · 2023Review
- Plant-based diet index and erectile dysfunction in the Health Professionals Follow-Up Study.BJU international · 2022Article
- The prospective randomized trial of the optimal evaluation of cardiac symptoms and revascularization: Rationale and design of the PRECISE trial.American heart journal · 2022Article
- Association of Diet With Erectile Dysfunction Among Men in the Health Professionals Follow-up Study.JAMA network open · 2020Article
- Prognostic Value of Coronary CTA in Stable Chest Pain: CAD-RADS, CAC, and Cardiovascular Events in PROMISE.JACC. Cardiovascular imaging · 2020Article
- Cardiac protection of germinated brown rice extract in rabbit model of chronic myocardial infarction.Translational animal science · 2020Article
- Preventive Management of Nonobstructive CAD After Coronary CT Angiography in the Emergency Department.JACC. Cardiovascular imaging · 2020Article
- Quantifying Sex Differences in Cardiovascular Care Among Patients Evaluated for Suspected Ischemic Heart Disease.Journal of women's health (2002) · 2019Article
- Ten-year association of coronary artery calcium with atherosclerotic cardiovascular disease (ASCVD) events: the multi-ethnic study of atherosclerosis (MESA).European heart journal · 2018Article
- Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundDiagnostic testing in the care of patients newly presenting with symptoms suggestive of coronary artery disease may influence risk factor management, independent of test type or test results. However, little is known about changes in medications and lifestyle after anatomical or functional testing. METHODS AND
resultsWe examined what factors influenced preventive medical therapy and lifestyle practices at 60 days among 10 003 symptomatic patients (53% women; mean age 61 years) randomly assigned to anatomical testing with coronary computed tomographic angiography or functional testing (NCT01174550). We also assessed the association of preventive changes with major cardiovascular events. There were no differences in medications/lifestyle at baseline. At 60 days, relative to baseline, the computed tomographic angiography strategy was associated with a higher proportion of patients newly initiating aspirin (11.8% versus 7.8%), statins (12.7% versus 6.2%), and β-blockers (8.1% versus 5.3%), compared to functional testing (P<0.0001 for each). No significant differences between computed tomographic angiography and functional testing strategies were observed for initiation of exercise, quitting smoking, or weight loss in overweight/obese patients, though overall prevalence of healthy eating was higher after computed tomographic angiography (P=0.002) while obese/overweight status was lower (P=0.040). Positive initial test results and revascularization demonstrated stronger associations with preventive medications and lifestyle than test type. Medication initiation was not associated with fewer cardiovascular events.
conclusionsPositive initial test results and revascularization are primary drivers of changes in preventive medical and lifestyle practices, with test type making secondary contributions. However, substantial opportunities exist to further reduce cardiovascular risk. CLINICAL
trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT01174550.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.