Evidence map›Paper›PMID 27733179›Full record

ReviewRadiation oncology (London, England)2016

Soft tissue sarcoma of the extremities: pending questions on surgery and radiotherapy.

Fien Hoefkens, Charlotte Dehandschutter, Johan Somville, Paul Meijnders, Dirk Van Gestel

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Radiation oncology (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06980259 (Spatially Fractionated Radiotherapy Versus Conventional Radiotherapy in the Treatment of Soft Tissue Sarcoma), which is not on this map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06980259 narecruitingnot on this mapstarted 2025, after this paper: background citation

Spatially Fractionated Radiotherapy Versus Conventional Radiotherapy in the Treatment of Soft Tissue Sarcoma:A Multicenter，Prospective, Phase II, Randomized Controlled Trial

TypeinterventionalSponsorShandong Cancer Hospital and InstituteRan2025 to 2028Enrolled106ConditionsSoft Tissue Sarcoma (STS)ArmsSpatially Fractionated Radiotherapy, Conventional Radiotherapy
3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Diagnosis and Management of Soft-Tissue Sarcomas: Current Insights.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Preoperative accelerated hypofractionated radiotherapy (PHYPORT): state of art and potential clinical application.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Monte Carlo dosimetric analyses on the use ofPhysics in medicine and biology · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fien HoefkensFaculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Charlotte DehandschutterFaculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Johan SomvilleFaculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Paul MeijndersFaculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Dirk Van GestelDepartment of Radiotherapy, University Radiotherapy Antwerp UZA/ZNA, Antwerp, Belgium. dirk.vangestel@bordet.be.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Soft tissue sarcomas are uncommon tumours of mesenchymal origin, most commonly arising in the extremities. Treatment includes surgical resection in combination with radiotherapy. Resection margins are of paramount importance in surgical treatment of soft tissue sarcomas but unambiguous guidelines for ideal margins of resection are still missing as is an uniform guideline on the use of radiotherapy.The present paper reviews the literature on soft tissue sarcomas of the extremities regarding the required resection margins, the impact of new radiotherapy techniques and the timing of radiotherapy, more particularly if it should be administered before or after surgical resection.This review was started by searching guidelines in different databases (National Guideline Clearinghouse, EBMPracticeNet, TRIP database, NCCN guidelines,…). After refinement of the query, more specific articles were found using MEDLINE, PubMed, Web of Science and Google Scholar. Used keywords include "soft tissue sarcoma"; "extremities OR limbs"; "radiotherapy", "surgery", "margins", "local recurrence" and "overall survival". Finally, the articles were selected based on the accessibility of the full text, use of the English language and relevance based on title and abstract.Literature demonstrates positive resection margins to be an important adverse prognostic factor for local recurrence of soft tissue sarcomas of the extremities. Still, no consensus is reached on the definition of what a good margin might be. The evolution of new radiation techniques, especially Intensity Modulated Radiotherapy, resulted in a s healthy surrounding tissues. However, the timing of radiotherapy treatment remains controversial as both preoperative and postoperative radiotherapy are characterised by several advantages and disadvantages.

Indexed as

ExtremitiesCombined Modality TherapyHumansNeoplasm MetastasisRadiotherapy DosageSarcomaSoft Tissue NeoplasmsExtremitiesRadiotherapySoft tissue sarcomaSurgery

Identifiers

PMID27733179
PMCPMC5062836

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.