ArticleBMC evolutionary biology2016
Variation in ligand responses of the bitter taste receptors TAS2R1 and TAS2R4 among New World monkeys.
Article in BMC evolutionary biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Functional Decline of a Bitter Receptor Gene in New World Vultures.Molecular biology and evolution · 2025Article
- The Remarkable Diversity of Vertebrate Bitter Taste Receptors: Recent Advances in Genomic and Functional Studies.International journal of molecular sciences · 2024Review
- Reduction of bitter taste receptor gene family in folivorous colobine primates relative to omnivorous cercopithecine primates.Primates; journal of primatology · 2024Article
- Activation of specific bitter taste receptors by olive oil phenolics and secoiridoids.Scientific reports · 2021Article
- Local Adaptation of Bitter Taste and Ecological Speciation in a Wild Mammal.Molecular biology and evolution · 2021Article
- Positive selection drives the evolution of a primate bitter taste receptor gene.Ecology and evolution · 2021Article
- The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Structure-Function Analyses of Human Bitter Taste Receptors-Where Do We Stand?Molecules (Basel, Switzerland) · 2020Review
- Variation in ligand responses of the bitter taste receptors TAS2R1 and TAS2R4 among New World monkeys.BMC evolutionary biology · 2016Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNew World monkeys (NWMs) are unique in that they exhibit remarkable interspecific variation in color vision and feeding behavior, making them an excellent model for studying sensory ecology. However, it is largely unknown whether non-visual senses co-vary with feeding ecology, especially gustation, which is expected to be indispensable in food selection. Bitter taste, which is mediated by bitter taste receptors (TAS2Rs) in the tongue, helps organisms avoid ingesting potentially toxic substances in food. In this study, we compared the ligand sensitivities of the TAS2Rs of five species of NWMs by heterologous expression in HEK293T cells and calcium imaging.
resultsWe found that TAS2R1 and TAS2R4 orthologs differ in sensitivity among the NWM species for colchicine and camphor, respectively. We then reconstructed the ancestral receptors of NWM TAS2R1 and TAS2R4, measured the evolutionary shift in ligand sensitivity, and identified the amino acid replacement at residue 62 as responsible for the high sensitivity of marmoset TAS2R4 to colchicine.
conclusionsOur results provide a basis for understanding the differences in feeding ecology among NWMs with respect to bitter taste.
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