Evidence map›Paper›PMID 27733020›Full record

Trial reportWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society2016

Topical oxygen therapy results in complete wound healing in diabetic foot ulcers.

Janelle Yu, Suzanne Lu, Ann-Marie McLaren, Julie A Perry, Karen M Cross

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03863054 (An Observational Clinical Trial Examining the Effect of Topical Oxygen Therapy), which is not on this map. Cited by 28 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 5 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03863054 completednot on this mapstarted 2018, after this paper: background citation

An Observational Clinical Trial Examining the Effect of Topical Oxygen Therapy (NATROX™) on the Rates of Healing of Chronic Diabetic Foot Ulcers

TypeobservationalSponsorSingapore General HospitalRan2018 to 2021Enrolled20ConditionsDiabetic Foot Ulcer, Non-healing WoundArmsNATROX™ Topical Oxygen Therapy System
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 5 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Review
  8. Review
  9. Article
  10. The Use of Oxygen Therapy in Management of Mastectomy Flap Ischemia.Plastic and reconstructive surgery. Global open · 2025
    Article
  11. Article
  12. Article
  13. An Observational Clinical Trial Examining the Effect of Topical Oxygen Therapy (NatroxThe international journal of lower extremity wounds · 2024
    Observational
  14. Article
  15. Review
  16. Article
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  18. Article
  19. Application of NATROX® topical oxygen therapy in neck wounds after radiotherapy.The British journal of oral & maxillofacial surgery · 2021
    Article
  20. Thermal Effects of Topical Hyperbaric Oxygen Therapy in Hard-to-Heal Wounds-A Pilot Study.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Janelle YuDivision of Plastic Surgery, St. Michael's Hospital, Toronto, Ontario, Canada.
Suzanne LuDivision of Plastic Surgery, St. Michael's Hospital, Toronto, Ontario, Canada.
Ann-Marie McLarenDivision of Plastic Surgery, St. Michael's Hospital, Toronto, Ontario, Canada.
Julie A PerryDivision of Plastic Surgery, St. Michael's Hospital, Toronto, Ontario, Canada.
Karen M CrossDivision of Plastic Surgery, St. Michael's Hospital, Toronto, Ontario, Canada.
St. Michael's Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic foot ulcers (DFUs) are a significant problem in an aging population. Fifteen percent of diabetics develop a DFU over their lifetime, which can lead to potential amputation. The 5-year survival rate after amputation is 31%, which is greater than the lifetime risk of mortality from cancer. Topical oxygen is a promising technique for the adjunctive therapy of chronic wounds including DFUs, but few controlled studies exist to support its clinical adoption. The aim of this study was to compare a portable topical oxygen delivery system in patients with nonhealing DFUs to standard best practice. Twenty patients were randomized into a topical oxygen group (n = 10), and a nonplacebo control group with regular dressings and standard care (n = 10), and attended the diabetic foot clinic once weekly for 8 weeks. Ulcer surface area over time was analyzed using standardized digital imaging software. DFUs were present without healing for a mean duration of 76 weeks prior to the study. They found a significant difference in healing rate between patients receiving topical oxygen and those receiving standard care. Topical oxygen, therefore, represents a potentially exciting new technology to shorten healing time in patients with nonhealing DFUs. More prospective randomized and powered studies are needed to determine the benefits of topical oxygen, but our current results are very promising.

Indexed as

Administration, TopicalAmputation, SurgicalDiabetic FootFemaleHumansMaleMiddle AgedOxygenPractice Guidelines as TopicProspective StudiesTreatment OutcomeWound HealingOxygen

Identifiers

PMID27733020
OpenAlexW2558745907

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.