ArticleBehavioural brain research2017
Decreasing GABA function within the medial prefrontal cortex or basolateral amygdala decreases sociability.
Article in Behavioural brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Social Communication in Ras Pathway Disorders: A Comprehensive Review From Genetics to Behavior in Neurofibromatosis Type 1 and Noonan Syndrome.Biological psychiatry · 2025Pooled it
- Neurodevelopmental effects of early life stress: PFC and cognition.Neuroscience and biobehavioral reviews · 2026Review
- Impact of early social isolation on social circuits and behavior: relevance to schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Animal models of autism spectrum disorder: Insights into genetic, structural and environmental models.Veterinarni medicina · 2025Review
- The Amygdala Regulates Social Motivation for Selective Vocal Imitation in Zebra Finches.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Altered socio-affective communication and amygdala development in mice with protocadherin10-deficient interneurons.Open biology · 2024Article
- Amygdalar neurotransmission alterations in the BTBR mice model of idiopathic autism.Translational psychiatry · 2024Article
- Increasing histone acetylation improves sociability and restores learning and memory in KAT6B-haploinsufficient mice.The Journal of clinical investigation · 2024Article
- Maturation of a cortical-amygdala circuit limits sociability in male rats.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Identifying novel proteins underlying loneliness by integrating GWAS summary data with human brain proteomes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Altered default mode network causal connectivity patterns in autism spectrum disorder revealed by Liang information flow analysis.Human brain mapping · 2023Article
- Anterior Insula-Associated Social Novelty Recognition: Pivotal Roles of a Local Retinoic Acid Cascade and Oxytocin Signaling.The American journal of psychiatry · 2023Article
- Liposaccharide-induced sustained mild inflammation fragments social behavior and alters basolateral amygdala activity.Psychopharmacology · 2023Article
- Article
- Effects of α5 GABACNS neuroscience & therapeutics · 2022Article
- mGluNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Modafinil Administration to Preadolescent Rat Impairs Non-Selective Attention, Frontal Cortex DInternational journal of molecular sciences · 2022Article
- Prenatal Poly I:C Challenge Affects Behaviors and Neurotransmission via Elevated Neuroinflammation Responses in Female Juvenile Rats.The international journal of neuropsychopharmacology · 2022Article
- Developmental Shifts in Amygdala Activity during a High Social Drive State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- GABAJournal, genetic engineering & biotechnology · 2021Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
introductionDecreased sociability is a symptom of psychiatric conditions including autism-spectrum disorder and schizophrenia. Both of these conditions are associated with decreases in GABA function, particularly in the medial prefrontal cortex (PFC) and the basolateral amygdala (BLA); structures that are components of the social brain. Here, we determined if decreasing GABA transmission within either the PFC or the BLA decreases social behavior.
methodsRats were implanted with cannulae aimed at either the medial PFC or the BLA and then were tested on up to 4 behavioral tests following bilateral infusions of 0.5μl bicuculline methiodide (BMI, a GABA
resultsIntra-BLA or PFC BMI infusions decreased the amount of time and the number of social interactions in the social interaction test. Further, in the social preference test, rats infused with 50ng BMI no longer exhibited a preference to explore a social over a non-social stimulus. The change in sociability was not due to a change in reward processing or locomotor behavior. DISCUSSION: Decreasing GABA transmission in either the medial PFC or BLA decreased sociability. Thus, changes in GABA signaling observed in conditions such as autism or schizophrenia may mediate the social withdrawal characteristic of these conditions. Moreover, they suggest that social withdrawal may be treated by drugs that potentiate GABA transmission.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.