Evidence map›Paper›PMID 27732871›Full record

ArticleToxicology and applied pharmacology2016

Estimation of human percutaneous bioavailability for two novel brominated flame retardants, 2-ethylhexyl 2,3,4,5-tetrabromobenzoate (EH-TBB) and bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP).

Gabriel A Knudsen, Michael F Hughes, J Michael Sanders, Samantha M Hall, Linda S Birnbaum

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology and applied pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Occurrence of Halogenated Pollutants in Domestic and Occupational Indoor Dust.International journal of environmental research and public health · 2020
    Article
  3. Article
  4. The biological fate of decabromodiphenyl ethane following oral, dermal or intravenous administration.Xenobiotica; the fate of foreign compounds in biological systems · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gabriel A KnudsenNCI Laboratory of Toxicology and Toxicokinetics, 111 T W Alexander Dr., Research Triangle Park, NC, USA. Electronic address: gabriel.knudsen@nih.gov.
Michael F HughesIntegrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
J Michael SandersNCI Laboratory of Toxicology and Toxicokinetics, 111 T W Alexander Dr., Research Triangle Park, NC, USA.
Samantha M HallNCI Laboratory of Toxicology and Toxicokinetics, 111 T W Alexander Dr., Research Triangle Park, NC, USA.
Linda S BirnbaumNCI Laboratory of Toxicology and Toxicokinetics, 111 T W Alexander Dr., Research Triangle Park, NC, USA.
Research Triangle Park Foundation · USEnvironmental Protection Agency · US

Funding

Studies of the fate of environmental contaminants in humans and animalsZIABC011476 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BIRNBAUM, LINDA · 2013 to 2019
$5.8M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA BC011476
6 · The paper itself

Abstract

2-Ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) and bis(2-ethylhexyl)tetrabromophthalate (BEH-TEBP) are novel brominated flame retardants used in consumer products. A parallelogram approach was used to predict human dermal absorption and flux for EH-TBB and BEH-TEBP. [ CHEMICAL COMPOUNDS STUDIED IN THIS ARTICLE: 2-Ethylhexyl 2,3,4,5-tetrabromobenzoate (PubChem CID: 71316600; CAS No. 183658-27-7 FW: 549.92g/mol logP

Indexed as

AgedAnimalsBenzoatesBiological AvailabilityFemaleFlame RetardantsHumansPhthalic AcidsRatsSkin2-ethylhexyl 2,3,4,5-tetrabromobenzoateBenzoatesbis(2-ethylhexyl) 2,3,4,5-tetrabromophthalateFlame RetardantsPhthalic Acids2-Ethylhexyl 2–3,4,5-tetrabromobenzoateBis(2-ethylhexyl) tetrabromophthalateBrominated flame retardantDermal bioavailabilityParallelogram methodPersistent organic pollutant

Identifiers

PMID27732871
PMCPMC5090262
OpenAlexW2531139426

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.