ArticleCell metabolism2016
NAD
2 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph
Article in Cell metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 349 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
349citing papers in PubMed, 1 pooled it
20.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT04870866 phase2active not recruitingnot on this mapstarted 2019, after this paper: background citation
NAD Supplementation to Prevent Progressive Neurological Disease in Ataxia Telangiectasia
Single Arm Open-label Clinical Trial in Ataxia-telangiectasia to Test the Effects of Nicotinamide Riboside on Ataxia Scales, Immune Function, and Neurofilament Light Chain.
Who cites it
349 citing papers in PubMed, 1 synthesis or guideline pooled it, 566 citations in OpenAlex.
- Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis.Frontiers in public health · 2023Pooled it
- Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double-Blind Randomized Crossover Placebo-Controlled Trial.Aging cell · 2025Trial
- Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.The Journal of clinical endocrinology and metabolism · 2023Trial
- Trial
- NADSpinal cord · 2026Review
- Mitochondrial NADP(H)-dependent de novo dTMP biosynthesis counteracts the cytotoxicity of PARP inhibitors.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Recent Advances in Therapy for the Neurodegenerative Disorder Ataxia-Telangiectasia.International journal of molecular sciences · 2026Review
- Nicotinamide riboside enhances adoptive T cell therapy by promoting memory differentiation and metabolic fitness.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Exercise and dietary interventions in the regulation of hepatic mitophagy and liver recovery (Review).Biomedical reports · 2026Review
- Redox Molecules in Aging and Neurodegenerative Disorders.International journal of molecular sciences · 2026Review
- Suppression of ATM kinase signaling accelerates cellular senescence.Stem cell reports · 2026Article
- Mitochondrial quality control in human ageing and longevity.Nature metabolism · 2026Review
- Transcriptional Profiling Shows Dampening of Interferon Gene Signatures by NADInternational journal of molecular sciences · 2026Article
- Reprogramming Neuroinflammation: Mitochondrial Targets and Immune Checkpoint Inhibitors in Alzheimer's Disease.Molecular neurobiology · 2026Review
- Mitophagy in Macrophages: A Metabolic Checkpoint in Inflammation-to-Repair Transition in Atherosclerosis.Journal of the American Heart Association · 2026Review
- Two-photon in vivo imaging reveals cell type-specific mitophagy dynamic changes in mouse somatosensory cortex during aging.npj aging · 2026Article
- Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer's disease pathology.Nature aging · 2026Article
- Organelle resilience as a comparative blueprint for longevity.EMBO molecular medicine · 2026Review
- Review
- CD8Science China. Life sciences · 2026Review
289 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
22 authors at 5 institutions in 4 countries.
Evandro Fei FangLaboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Henok KassahunInstitute of Clinical Medicine, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway.
Deborah L CroteauLaboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Morten Scheibye-KnudsenLaboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA; Danish Center for Healthy Aging, University of Copenhagen, Copenhagen, Blegdamsvej 3B 2200, Denmark.
Krisztina MarosiLaboratory of Neurosciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Huiming LuLaboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Raghavendra A ShamannaLaboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Sumana KalyanasundaramInstitute of Clinical Medicine, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway; Bioinformatics Core Facility, Department of Core Facilities, Institute of Cancer Research, Radium Hospital, Oslo University Hospital, 0379 Oslo, Norway.
Ravi Chand BollineniDepartment of Biosciences, University of Oslo, 0316 Oslo, Norway.
Mark A WilsonLaboratory of Neurosciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Wendy B IserLaboratory of Neurosciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Bradley N WollmanLaboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Marya MorevatiLaboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA; Danish Center for Healthy Aging, University of Copenhagen, Copenhagen, Blegdamsvej 3B 2200, Denmark.
Jun LiDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Jesse S KerrLaboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Qiping LuLaboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Tyler B WaltzLaboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Jane TianLaboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
David A SinclairDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney NSW 2052, Australia.
Mark P MattsonLaboratory of Neurosciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA; Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Hilde NilsenInstitute of Clinical Medicine, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway.
Vilhelm A BohrLaboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA; Danish Center for Healthy Aging, University of Copenhagen, Copenhagen, Blegdamsvej 3B 2200, Denmark. Electronic address: vbohr@nih.gov.
National Institute on Aging · USUniversity of Oslo · NOHarvard University · USUniversity of Copenhagen · DKOslo University Hospital · NO
Funding
DNA repair dysfunction in neurodegeneration and Alzheimer's DiseaseZIAAG000723 · NIA · NATIONAL INSTITUTE ON AGING · PI BROSH, ROBERT · 2009 to 2025
$9.5MOxidative DNA Damage And Its ProcessingZIAAG000727 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2009 to 2022
$8.4MSIRT1 as a regulator of health and lifespan of mammalsR37AG028730 · NIA · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2012 to 2021
$4.1MNIA NIH HHS R37 AG028730
Abstract
Ataxia telangiectasia (A-T) is a rare autosomal recessive disease characterized by progressive neurodegeneration and cerebellar ataxia. A-T is causally linked to defects in ATM, a master regulator of the response to and repair of DNA double-strand breaks. The molecular basis of cerebellar atrophy and neurodegeneration in A-T patients is unclear. Here we report and examine the significance of increased PARylation, low NAD
Indexed as
HealthAnimalsAtaxia TelangiectasiaAtaxia Telangiectasia Mutated ProteinsBehavior, AnimalCaenorhabditis elegansCells, CulturedDisease Models, AnimalDNA RepairGene Knockdown TechniquesHomeostasisLongevityMetabolomicsMiceMitophagyNADAtaxia Telangiectasia Mutated ProteinsNADolaparibPhthalazinesPiperazinesSirtuin 1
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
NCT04870866ClinicalTrials.gov
NCT06324877ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.