Evidence map›Paper›PMID 27732833›Full record

ArticleCell metabolism2016

Hypothesis Driven versus Hypothesis-free: Filling the Gaps in CoQ Biosynthesis.

José Antonio Enríquez, Fátima Sánchez-Cabo, Jesús Vázquez

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Biochemistry of Mitochondrial Coenzyme Q Biosynthesis.Trends in biochemical sciences · 2017
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

José Antonio EnríquezCentro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain; Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, 50009 Zaragoza, Spain. Electronic address: jaenriquez@cnic.es.
Fátima Sánchez-CaboCentro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain.
Jesús VázquezCentro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two independent investigations based on the power of yeast genetics, but using radically different discovery-driven approaches, have solved a long-pursued goal: the understanding of the early steps in CoQ biosynthesis, which may help diagnose CoQ deficiencies of unknown origin (Payet et al., 2016; Stefely et al., 2016).

Indexed as

Mitochondrial DiseasesUbiquinoneAtaxiaMuscle WeaknessUbiquinone

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.