Evidence map›Paper›PMID 27732792›Full record

ReviewAnnual review of genetics2016

Cell-Specific Targeting of Genetically Encoded Tools for Neuroscience.

Lucas Sjulson, Daniela Cassataro, Shamik DasGupta, Gero Miesenböck

Abstract readReview
In one paragraph

Review in Annual review of genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Applications of chemogenetics in non-human primates.Current opinion in pharmacology · 2022
    Review
  16. Article
  17. Gephyrin-Lacking PV Synapses on Neocortical Pyramidal Neurons.International journal of molecular sciences · 2021
    Article
  18. Changes in Presynaptic Gene Expression during Homeostatic Compensation at a Central Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lucas SjulsonDepartment of Psychiatry, New York University School of Medicine, New York, NY 10016; email: lukesjulson@gmail.com.
Daniela CassataroDepartment of Neuroscience and Physiology, Smilow Neuroscience Program, and New York University Neuroscience Institute, New York, NY 10016.
Shamik DasGuptaCentre for Neural Circuits and Behaviour, University of Oxford, Oxford, OX1 3SR, United Kingdom; email: gero.miesenboeck@cncb.ox.ac.uk.
Gero MiesenböckCentre for Neural Circuits and Behaviour, University of Oxford, Oxford, OX1 3SR, United Kingdom; email: gero.miesenboeck@cncb.ox.ac.uk.

Funding

Accumbens Neuronal Subtypes in AddictionK08DA036657 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SJULSON, LUCAS L · 2014 to 2017
$947k
Medical Research Council G0700888Medical Research Council G0701225NIDA NIH HHS K08 DA036657Wellcome Trust
6 · The paper itself

Abstract

Genetically encoded tools for visualizing and manipulating neurons in vivo have led to significant advances in neuroscience, in large part because of the ability to target expression to specific cell populations of interest. Current methods enable targeting based on marker gene expression, development, anatomical projection pattern, synaptic connectivity, and recent activity as well as combinations of these factors. Here, we review these methods, focusing on issues of practical implementation as well as areas for future improvement.

Indexed as

Genetic TechniquesAnimalsAnimals, Genetically ModifiedGene ExpressionGene Transfer TechniquesHumansNeuronsNeurosciencesPromoter Regions, GeneticTransgenesactuatorchemogeneticseffectoroptogeneticsreportertransgene expressionviral vector

Identifiers

PMID27732792
PMCPMC5630135

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.