Evidence map›Paper›PMID 27732780›Full record

ArticleAnalytical chemistry2016

Mass Spectrometry-Based Visualization of Molecules Associated with Human Habitats.

Daniel Petras, Louis-Félix Nothias, Robert A Quinn, Theodore Alexandrov, Nuno Bandeira, Amina Bouslimani, Gabriel Castro-Falcón, Liangyu Chen, Tam Dang, Dimitrios J Floros and 33 more

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 54 citations in OpenAlex.

  1. Early seed priming with closely relatedHorticulture research · 2026
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  3. Forensic Mass Spectrometry: Scientific and Legal Precedents.Journal of the American Society for Mass Spectrometry · 2023
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  5. Chemical Cartography Approaches to Study Trypanosomatid Infection.Journal of visualized experiments : JoVE · 2022
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  15. Detection of Natural Products and Their Producers in Ocean Sediments.Applied and environmental microbiology · 2019
    Article
  16. A multi-laboratory investigation of drug background levels.Forensic chemistry (Amsterdam, Netherlands) · 2019
    Article
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors at 7 institutions in 4 countries.

Daniel PetrasUCSD Collaborative Mass Spectrometry Innovation Center, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Louis-Félix NothiasUCSD Collaborative Mass Spectrometry Innovation Center, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Robert A QuinnUCSD Collaborative Mass Spectrometry Innovation Center, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Theodore AlexandrovUCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Nuno BandeiraUCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Amina BouslimaniUCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Gabriel Castro-FalcónScripps Institution of Oceanography, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Liangyu ChenUCSD Collaborative Mass Spectrometry Innovation Center, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Tam DangUCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Dimitrios J FlorosUCSD Mathematics Undergraduate Program, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Vivian HookUCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Neha GargFacultad de Medicina de la Universidad Autónoma de Madrid . Calle del Arzobispo Morcillo 4. 28029 Madrid, Spain.
Nicole HoffnerUCSD Neurosciences Graduate Program, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Yike JiangUCSD Biological Sciences Graduate Program, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Clifford A KaponoUCSD Chemistry and Biochemistry, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Irina KoesterScripps Institution of Oceanography, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Rob KnightUCSD Department of Computer Science, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Christopher A LeberScripps Institution of Oceanography, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Tie-Jun LingFacultad de Medicina de la Universidad Autónoma de Madrid . Calle del Arzobispo Morcillo 4. 28029 Madrid, Spain.
Tal Luzzatto-KnaanFacultad de Medicina de la Universidad Autónoma de Madrid . Calle del Arzobispo Morcillo 4. 28029 Madrid, Spain.
Laura-Isobel McCallUCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Aaron P McGrathUCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Michael J MeehanFacultad de Medicina de la Universidad Autónoma de Madrid . Calle del Arzobispo Morcillo 4. 28029 Madrid, Spain.
Jonathan K MerrittUCSD Neurosciences Graduate Program, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Robert H MillsUCSD Biomedical Sciences Graduate Program, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Jamie MortonUCSD Department of Computer Science, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Sonia PodvinUCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Ivan ProtsyukStructural and Computational Biology, EMBL, Meyerhofstrasse 1, 69117 Heidelberg, German y.
Trevor PurdyScripps Institution of Oceanography, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Kendall SatterfieldUCSD Biomedical Sciences Graduate Program, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Stephen SearlesUCSD Department of Pathology, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Sahil ShahUCSD Neurosciences Graduate Program, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Sarah ShiresUCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Dana SteffenUCSD Biomedical Sciences Graduate Program, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Margot WhiteScripps Institution of Oceanography, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Jelena TodoricUCSD Department of Pharmacology, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Robert TuttleScripps Institution of Oceanography, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Aneta WojniczFacultad de Medicina de la Universidad Autónoma de Madrid . Calle del Arzobispo Morcillo 4. 28029 Madrid, Spain.
Valerie SappUCSD Biomedical Sciences Graduate Program, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Fernando VargasUCSD Biological Sciences Graduate Program, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Jin YangUCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Chao ZhangUCSD Bioengineering Undergraduate Program, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
Pieter C DorresteinUCSD Collaborative Mass Spectrometry Innovation Center, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
University of California, San Diego · USUniversity of Montana · USUniversidad Autónoma de Madrid · ESAnhui Agricultural University · CNEuropean Molecular Biology Organization · DEScripps Institution of Oceanography · USTechnische Universität Berlin · DE

Funding

GRADUATE TRAINING IN CELLULAR &MOLECULAR PHARMACOLOGYT32GM007752 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER, HANDEL, TRACY M · 1985 to 2023
$13.5M
Neurosciences Graduate Training ProgramT32NS061847 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Brenda L Bloodgood · 2008 to 2026
$7.7M
Training Program in Marine BiotechnologyT32GM067550 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GERWICK, WILLIAM HENRY · 2004 to 2019
$2.0M
Howard Hughes Medical InstituteNIGMS NIH HHS T32 GM007752NIGMS NIH HHS T32 GM067550NINDS NIH HHS T32 NS061847
6 · The paper itself

Abstract

The cars we drive, the homes we live in, the restaurants we visit, and the laboratories and offices we work in are all a part of the modern human habitat. Remarkably, little is known about the diversity of chemicals present in these environments and to what degree molecules from our bodies influence the built environment that surrounds us and vice versa. We therefore set out to visualize the chemical diversity of five built human habitats together with their occupants, to provide a snapshot of the various molecules to which humans are exposed on a daily basis. The molecular inventory was obtained through untargeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of samples from each human habitat and from the people that occupy those habitats. Mapping MS-derived data onto 3D models of the environments showed that frequently touched surfaces, such as handles (e.g., door, bicycle), resemble the molecular fingerprint of the human skin more closely than other surfaces that are less frequently in direct contact with humans (e.g., wall, bicycle frame). Approximately 50% of the MS/MS spectra detected were shared between people and the environment. Personal care products, plasticizers, cleaning supplies, food, food additives, and even medications that were found to be a part of the human habitat. The annotations indicate that significant transfer of chemicals takes place between us and our built environment. The workflows applied here will lay the foundation for future studies of molecular distributions in medical, forensic, architectural, space exploration, and environmental applications.

Indexed as

EcosystemMass SpectrometryChromatography, LiquidHumansIonsOrganic ChemicalsTandem Mass SpectrometryIonsOrganic Chemicals

Identifiers

PMID27732780
PMCPMC6326777
OpenAlexW2530395773

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.