Observational studyThe Journal of clinical endocrinology and metabolism2017
Vertebral Volumetric Bone Density and Strength Are Impaired in Women With Low-Weight and Atypical Anorexia Nervosa.
Observational study in The Journal of clinical endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Sequential Therapy With Recombinant Human IGF-1 Followed by Risedronate Increases Spine Bone Mineral Density in Women With Anorexia Nervosa: A Randomized, Placebo-Controlled Trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Trial
- QCT-based geometric, densitometric, and biomechanical properties of the aging human thoracolumbar spine.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Comparison of disease severity in adolescents with anorexia nervosa and atypical anorexia nervosa.European journal of pediatrics · 2025Article
- Deficits in volumetric bone mineral density, bone microarchitecture, and estimated bone strength in women with atypical anorexia nervosa compared to healthy controls.The International journal of eating disorders · 2024Article
- Baseline presentation of atypical anorexia nervosa in Singaporean adolescents: a retrospective cohort study.Journal of eating disorders · 2023Article
- Nutrient regulation of bone marrow adipose tissue: skeletal implications of weight loss.Nature reviews. Endocrinology · 2023Review
- Article
- Medical complications and management of atypical anorexia nervosa.Journal of eating disorders · 2022Review
- Medical considerations in the care of transgender and gender diverse patients with eating disorders.Journal of eating disorders · 2022Review
- Article
- Management of eating disorders for people with higher weight: clinical practice guideline.Journal of eating disorders · 2022Article
- Exploring the experience of being viewed as "not sick enough": a qualitative study of women recovered from anorexia nervosa or atypical anorexia nervosa.Journal of eating disorders · 2021Article
- Predictors of bone mineral density in adolescents with atypical anorexia nervosa.Journal of bone and mineral metabolism · 2021Article
- Bone mineral density and estimated hip strength in men with anorexia nervosa, atypical anorexia nervosa and avoidant/restrictive food intake disorder.Clinical endocrinology · 2019Article
- Anorexia Nervosa and Bone.Current opinion in endocrine and metabolic research · 2018Article
- Neuroactive Steroids and Affective Symptoms in Women Across the Weight Spectrum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Osteoporosis in Children with Chronic Illnesses: Diagnosis, Monitoring, and Treatment.Current osteoporosis reports · 2017Review
- Eating disorders and bone metabolism in women.Current opinion in pediatrics · 2017Review
- Defining "significant weight loss" in atypical anorexia nervosa.The International journal of eating disorders · 2017Article
Corrections and comments
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Authors and funding
20 authors at 4 institutions in 1 country.
Funding
Abstract
Context: Areal bone mineral density (BMD) is lower, particularly at the spine, in low-weight women with anorexia nervosa (AN). However, little is known about vertebral integral volumetric BMD (Int.vBMD) or vertebral strength across the AN weight spectrum, including "atypical" AN [body mass index (BMI) ≥18.5 kg/m2]. Objective: To investigate Int.vBMD and vertebral strength, and their determinants, across the AN weight spectrum. Design: Cross-sectional observational study. Setting: Clinical research center. Participants: 153 women (age 18 to 45): 64 with low-weight AN (BMI <18.5 kg/m2; 58% amenorrheic), 44 with atypical AN (18.5≤BMI<23 kg/m2; 30% amenorrheic), 45 eumenorrheic controls (19.2≤BMI<25 kg/m2). Measures: Int.vBMD and cross-sectional area (CSA) by quantitative computed tomography of L4; estimated vertebral strength (derived from Int.vBMD and CSA). Results: Int.vBMD and estimated vertebral strength were lowest in low-weight AN, intermediate in atypical AN, and highest in controls. CSA did not differ between groups; thus, vertebral strength (calculated using Int.vBMD and CSA) was driven by Int.vBMD. In AN, Int.vBMD and vertebral strength were associated positively with current BMI and nadir lifetime BMI (independent of current BMI). Int.vBMD and vertebral strength were lower in AN with current amenorrhea and longer lifetime amenorrhea duration. Among amenorrheic AN, Int.vBMD and vertebral strength were associated positively with testosterone. Conclusions: Int.vBMD and estimated vertebral strength (driven by Int.vBMD) are impaired across the AN weight spectrum and are associated with low BMI and endocrine dysfunction, both current and previous. Women with atypical AN experience diminished vertebral strength, partially due to prior low-weight and/or amenorrhea. Lack of current low-weight or amenorrhea in atypical AN does not preclude compromise of vertebral strength.
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Registered trials
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