Evidence map›Paper›PMID 27732091›Full record

ArticleJournal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53

Early Detection of ADHD: Insights From Infant Siblings of Children With Autism.

Meghan Miller, Ana-Maria Iosif, Gregory S Young, Monique Moore Hill, Sally Ozonoff

Abstract read
In one paragraph

Article in Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Patterns of Early Development in Children with ADHD.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Infant attention and frontal EEG neuromarkers of childhood ADHD.Developmental cognitive neuroscience · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Meghan Millera MIND Institute , University of California , Davis Health System.
Ana-Maria Iosifb Department of Public Health Sciences , University of California , Davis Health System.
Gregory S Younga MIND Institute , University of California , Davis Health System.
Monique Moore Hilla MIND Institute , University of California , Davis Health System.
Sally Ozonoffa MIND Institute , University of California , Davis Health System.
University of California, Davis · USUC Davis Health System · US

Funding

Rodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI OZONOFF, SALLY · 2013 to 2019
$8.5M
Infants at Risk of Autism: A Longitudinal StudyR01MH068398 · NIMH · UNIVERSITY OF CALIFORNIA DAVIS · PI OZONOFF, SALLY · 2003 to 2013
$6.1M
Longitudinal Investigation of Social-Communication and Attention Processes in School-Aged Children at Genetic Risk for AutismR01MH109541 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI OZONOFF, SALLY · 2016 to 2020
$3.2M
Shared and Distinct Developmental Pathways to ADHD and Autism Spectrum DisorderR00MH106642 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MILLER, MEGHAN RHYS · 2017 to 2020
$863k
Shared and Distinct Developmental Pathways to ADHD and Autism Spectrum DisorderK99MH106642 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MILLER, MEGHAN RHYS · 2015 to 2016
$164k
NICHD NIH HHS U54 HD079125NIMH NIH HHS K99 MH106642NIMH NIH HHS R00 MH106642NIMH NIH HHS R01 MH068398NIMH NIH HHS R01 MH109541
6 · The paper itself

Abstract

Converging evidence suggests shared genetic underpinnings of attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Studies of infants at risk for ASD have proliferated over the past decade; the few studies that have followed these infants beyond age 3 report a range of difficulties facing a subset of these infants as they reach school age, including elevated levels of attention problems and externalizing behavior. Given this, we aimed to identify early predictors of school-age ADHD outcomes in a sample of infant siblings at risk for ASD. This study reports on a sample of 59 infants at high and low risk for ASD who had been followed for more than a decade, collecting data at regular intervals from 3 to 36 months and then determining diagnostic outcome at 8-10 years of age. Seventeen participants were diagnosed with Diagnostic and Statistical Manual of Mental Disorders (5th ed.) ADHD at school age (n = 14 high risk, 3 low risk). As infants, the ADHD outcome group demonstrated atypical longitudinal patterns of sustained visual attention. A significantly larger proportion of their parents reported behavior/temperament problems at 36 months of age, and examiners noted the presence of inattentive, hyperactive, and/or impulsive behaviors in this group by 18 months of age. These data suggest that behavioral indicators of risk for later ADHD may be present early in development, which may improve earlier detection and treatment of the disorder.

Indexed as

Attention Deficit Disorder with HyperactivityAutistic DisorderChildChild, PreschoolDiagnostic and Statistical Manual of Mental DisordersEarly DiagnosisFemaleFollow-Up StudiesHumansImpulsive BehaviorInfantMaleParentsProblem SolvingProspective StudiesSiblings

Identifiers

PMID27732091
PMCPMC5436956
OpenAlexW2531481231

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.