Evidence map›Paper›PMID 27732090›Full record

ArticleEndocrinology2016

Neuregulin 1 Regulates Proliferation of Leydig Cells to Support Spermatogenesis and Sexual Behavior in Adult Mice.

Takashi Umehara, Ikko Kawashima, Tomoko Kawai, Yumi Hoshino, Ken-Ichirou Morohashi, Yuichi Shima, Wenxian Zeng, JoAnne S Richards, Masayuki Shimada

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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  5. A Testis-Specific Long Noncoding RNA,Frontiers in endocrinology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Takashi UmeharaGraduate School of Biosphere Science (T.U., I.K., T.K., Y.H., W.Z., M.S.), Hiroshima University, Higashi-Hiroshima 7398528, Japan; Laboratory of Sex Differentiation (K.M., Y.S.), Graduate School of Medicine, Kyusyu University, Fukuoka 8258585, Japan; College of Animal Science and Technology (W.Z., Y.S.), Northwest A&F University, Yangling, 712100 China; and Department of Molecular and Cellular Biology (J.S.R.), Baylor College of Medicine, Houston, Texas 77030.
Ikko KawashimaGraduate School of Biosphere Science (T.U., I.K., T.K., Y.H., W.Z., M.S.), Hiroshima University, Higashi-Hiroshima 7398528, Japan; Laboratory of Sex Differentiation (K.M., Y.S.), Graduate School of Medicine, Kyusyu University, Fukuoka 8258585, Japan; College of Animal Science and Technology (W.Z., Y.S.), Northwest A&F University, Yangling, 712100 China; and Department of Molecular and Cellular Biology (J.S.R.), Baylor College of Medicine, Houston, Texas 77030.
Tomoko KawaiGraduate School of Biosphere Science (T.U., I.K., T.K., Y.H., W.Z., M.S.), Hiroshima University, Higashi-Hiroshima 7398528, Japan; Laboratory of Sex Differentiation (K.M., Y.S.), Graduate School of Medicine, Kyusyu University, Fukuoka 8258585, Japan; College of Animal Science and Technology (W.Z., Y.S.), Northwest A&F University, Yangling, 712100 China; and Department of Molecular and Cellular Biology (J.S.R.), Baylor College of Medicine, Houston, Texas 77030.
Yumi HoshinoGraduate School of Biosphere Science (T.U., I.K., T.K., Y.H., W.Z., M.S.), Hiroshima University, Higashi-Hiroshima 7398528, Japan; Laboratory of Sex Differentiation (K.M., Y.S.), Graduate School of Medicine, Kyusyu University, Fukuoka 8258585, Japan; College of Animal Science and Technology (W.Z., Y.S.), Northwest A&F University, Yangling, 712100 China; and Department of Molecular and Cellular Biology (J.S.R.), Baylor College of Medicine, Houston, Texas 77030.
Ken-Ichirou MorohashiGraduate School of Biosphere Science (T.U., I.K., T.K., Y.H., W.Z., M.S.), Hiroshima University, Higashi-Hiroshima 7398528, Japan; Laboratory of Sex Differentiation (K.M., Y.S.), Graduate School of Medicine, Kyusyu University, Fukuoka 8258585, Japan; College of Animal Science and Technology (W.Z., Y.S.), Northwest A&F University, Yangling, 712100 China; and Department of Molecular and Cellular Biology (J.S.R.), Baylor College of Medicine, Houston, Texas 77030.
Yuichi ShimaGraduate School of Biosphere Science (T.U., I.K., T.K., Y.H., W.Z., M.S.), Hiroshima University, Higashi-Hiroshima 7398528, Japan; Laboratory of Sex Differentiation (K.M., Y.S.), Graduate School of Medicine, Kyusyu University, Fukuoka 8258585, Japan; College of Animal Science and Technology (W.Z., Y.S.), Northwest A&F University, Yangling, 712100 China; and Department of Molecular and Cellular Biology (J.S.R.), Baylor College of Medicine, Houston, Texas 77030.
Wenxian ZengGraduate School of Biosphere Science (T.U., I.K., T.K., Y.H., W.Z., M.S.), Hiroshima University, Higashi-Hiroshima 7398528, Japan; Laboratory of Sex Differentiation (K.M., Y.S.), Graduate School of Medicine, Kyusyu University, Fukuoka 8258585, Japan; College of Animal Science and Technology (W.Z., Y.S.), Northwest A&F University, Yangling, 712100 China; and Department of Molecular and Cellular Biology (J.S.R.), Baylor College of Medicine, Houston, Texas 77030.
JoAnne S RichardsGraduate School of Biosphere Science (T.U., I.K., T.K., Y.H., W.Z., M.S.), Hiroshima University, Higashi-Hiroshima 7398528, Japan; Laboratory of Sex Differentiation (K.M., Y.S.), Graduate School of Medicine, Kyusyu University, Fukuoka 8258585, Japan; College of Animal Science and Technology (W.Z., Y.S.), Northwest A&F University, Yangling, 712100 China; and Department of Molecular and Cellular Biology (J.S.R.), Baylor College of Medicine, Houston, Texas 77030.
Masayuki ShimadaGraduate School of Biosphere Science (T.U., I.K., T.K., Y.H., W.Z., M.S.), Hiroshima University, Higashi-Hiroshima 7398528, Japan; Laboratory of Sex Differentiation (K.M., Y.S.), Graduate School of Medicine, Kyusyu University, Fukuoka 8258585, Japan; College of Animal Science and Technology (W.Z., Y.S.), Northwest A&F University, Yangling, 712100 China; and Department of Molecular and Cellular Biology (J.S.R.), Baylor College of Medicine, Houston, Texas 77030.
Baylor College of Medicine · USHiroshima University · JPNorthwest A&F University · CN

Funding

Mechanisms Controlling Divergent Fates of Ovarian Follicles and FertilityR01HD076980 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI RICHARDS, JOANNE STEWART · 2014 to 2018
$1.9M
NICHD NIH HHS R01 HD076980
6 · The paper itself

Abstract

Adult Leydig cells are derived from proliferating stem/progenitor Leydig cells in the infant testis and subsequent differentiation to steroidogenic cells in adult mice. Leydig cell proliferation in the infant testis occurs primarily in response to increased levels of LH that induce Leydig cell expression of neuregulin 1 (NRG1). Depletion of NRG1 in Nrg1 mutant mice (Nrg1

Indexed as

AnimalsCell ProliferationLeydig CellsMaleMiceMice, KnockoutNeuregulin-1Sexual Behavior, AnimalSpermatogenesisTestosteroneNeuregulin-1Testosterone

Identifiers

PMID27732090
PMCPMC5133346
OpenAlexW2531666970

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.