Evidence map›Paper›PMID 27732034›Full record

Trial reportPsychiatric rehabilitation journal2017

A randomized controlled trial of cognitive remediation and work therapy in the early phase of substance use disorder recovery for older veterans: Neurocognitive and substance use outcomes.

Morris D Bell, Holly B Laws, Ismene B Petrakis

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychiatric rehabilitation journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  6. Modified cognitive behavioral therapy (M-CBT) for cocaine dependence: Development of treatment for cognitively impaired users and results from a Stage 1 trial.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2018
    Trial
  7. Substance Use Disorder and Cognitive Impairment.Life (Basel, Switzerland) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Morris D BellDepartment of Psychiatry, Yale University School of Medicine.
Holly B LawsDepartment of Psychiatry, Yale University School of Medicine.
Ismene B PetrakisDepartment of Psychiatry, Yale University School of Medicine.

Funding

Cognitive Remediation and Work Therapy in the Initial Phase of Substance Abuse TrR21DA030744 · NIDA · YALE UNIVERSITY · PI BELL, MORRIS D. · 2010 to 2011
$353k
RR&D Senior Research Career Scientist AwardIK6RX002458 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI MORRIS D. BELL · 2017 to 2026
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NIDA NIH HHS R21 DA030744RRD VA IK6 RX002458
6 · The paper itself

Abstract

objectiveCognitive remediation therapy (CRT) is reported to improve neurocognitive and substance use disorder (SUD) outcomes in residential treatments. This National Institute of Drug Abuse funded pilot study reports on CRT as an augmentation to outpatient treatment for SUD.

methodRecovering outpatient veterans were randomized into CRT + Work Therapy (n = 24) or work therapy (n = 24) with treatment-as-usual. Blind assessments of neurocognition and substance use were performed at baseline, 3 months (end of treatment), and 6-month follow-up.

resultsBaseline assessments revealed high rates of cognitive impairment with 87.5% showing significant decline from premorbid IQ on at least 1 measure (median = 3/14 measures). Adherence to treatment was excellent. Follow-up rates were 95.7% at 3 months and 87.5% at 6 months. Mixed effects models of cognitive change over time revealed significant differences favoring CRT + Work Therapy on working memory (WM) and executive function indices. Global index of cognition showed a nonsignificant trend (effect size [ES] = .37) favoring CRT + Work Therapy. SUD outcomes were excellent for both conditions. CRT + Work Therapy had a mean of 97% days of abstinence at 3 months, 94% in the 30 days prior to 6-month follow-up, and 24/26 weeks of total abstinence; differences between conditions were not significant. CONCLUSIONS AND IMPLICATIONS FOR PRACTICE: CRT was well accepted by outpatient veterans with SUDs and led to significant improvements in WM and executive functions beyond that of normal cognitive recovery. No difference between conditions was found for SUD outcomes, perhaps because work therapy obscured the benefits of CRT. (PsycINFO Database Record

Indexed as

VeteransAdultCognitive DysfunctionCognitive RemediationExecutive FunctionFemaleFollow-Up StudiesHumansMaleMemory, Short-TermMiddle AgedPilot ProjectsRehabilitation, VocationalSubstance-Related Disorders

Identifiers

PMID27732034
PMCPMC5378626

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.