ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2017
The Perioperative Lung Transplant Virome: Torque Teno Viruses Are Elevated in Donor Lungs and Show Divergent Dynamics in Primary Graft Dysfunction.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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66 citing papers in PubMed, 112 citations in OpenAlex.
- Genetic Diversity and Genomic Characteristics of the Respiratory Virome in Patients With Severe Fungal Infections.Journal of medical virology · 2026Article
- Optimizing methods for virome analysis based on studies of a synthetic viral community.mSystems · 2026Article
- Crosstalk between the microbiome and the mucosal immunoglobulin A system in the lung, in health and disease.Frontiers in cellular and infection microbiology · 2026Review
- Omics Approaches to Unraveling the Complexity of the Gut-Lung Axis.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Enrichment of the commensal microbiome in the lower respiratory tract is associated with improved outcomes following lung transplantation.Chinese medical journal pulmonary and critical care medicine · 2025Article
- The Human Respiratory Virome in Health and Disease: Interactions, Dysbiosis, and Methodological Challenges.Advanced genetics (Hoboken, N.J.) · 2025Review
- Identification and characterization of novel CRESS-DNA viruses in the human respiratory tract.Virology journal · 2025Article
- Torque Teno Virus: Lights and Shades.Viruses · 2025Review
- Lung Microbiota: From Healthy Lungs to Development of Chronic Obstructive Pulmonary Disease.International journal of molecular sciences · 2025Review
- Long-term air pollution exposure and the risk of primary graft dysfunction after lung transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025Observational
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- Torque Teno Virus (TTV) in Renal Transplant Recipients: Species Diversity and Variability.Viruses · 2024Article
- The Microbiome and Pediatric Transplantation.Journal of the Pediatric Infectious Diseases Society · 2024Review
- Article
- Exploring the Human Virome: Composition, Dynamics, and Implications for Health and Disease.Current microbiology · 2023Review
- Expansion ofViruses · 2023Article
- Early cryptococcosis infection in a liver transplant patient: A case report.Clinical case reports · 2023Article
- Respiratory eukaryotic virome expansion and bacteriophage deficiency characterize childhood asthma.Scientific reports · 2023Article
- Unmasking the tissue-resident eukaryotic DNA virome in humans.Nucleic acids research · 2023Article
- The persistence and stabilization of auxiliary genes in the human skin virome.Virology journal · 2023Article
6 more citing papers are in PubMed but not listed here.
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17 authors at 3 institutions in 1 country.
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Abstract
Primary graft dysfunction (PGD) is a principal cause of early morbidity and mortality after lung transplantation, but its pathogenic mechanisms are not fully clarified. To date, studies using standard clinical assays have not linked microbial factors to PGD. We previously used comprehensive metagenomic methods to characterize viruses in lung allografts >1 mo after transplant and found that levels of Anellovirus, mainly torque teno viruses (TTVs), were significantly higher than in nontransplanted healthy controls. We used quantitative polymerase chain reaction to analyze TTV and shotgun metagenomics to characterize full viral communities in acellular bronchoalveolar lavage from donor organs and postreperfusion allografts in PGD and non-PGD lung transplant recipient pairs. Unexpectedly, TTV DNA levels were elevated 100-fold in donor lungs compared with healthy adults (p = 0.0026). Although absolute TTV levels did not differ by PGD status, PGD cases showed a smaller increase in TTV levels from before to after transplant than did control recipients (p = 0.041). Metagenomic sequencing revealed mainly TTV and bacteriophages of respiratory tract bacteria, but no viral taxa distinguished PGD cases from controls. These findings suggest that conditions associated with brain death promote TTV replication and that greater immune activation or tissue injury associated with PGD may restrict TTV abundance in the lung.
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