ArticleeLife2016
Primate amygdala neurons evaluate the progress of self-defined economic choice sequences.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Value coding by primate amygdala neurons complies with the continuity axiom of economic choice theory.Journal of neurophysiology · 2026Article
- Differential and Temporally Dynamic Involvement of Primate Amygdala Nuclei in Face Reality and Reward Information Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dynamic coding and sequential integration of multiple reward attributes by primate amygdala neurons.Nature communications · 2025Article
- Social Risk Coding by Amygdala Activity and Connectivity with the Dorsal Anterior Cingulate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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- The amygdala and the pursuit of future rewards.Frontiers in neuroscience · 2024Review
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- Functions of primate amygdala neurons in economic decisions and social decision simulation.Behavioural brain research · 2021Review
- Experimentally revealed stochastic preferences for multicomponent choice options.Journal of experimental psychology. Animal learning and cognition · 2020Article
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- Neuronal Activity in the Primate Amygdala during Economic Choice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Neural Mechanisms for Accepting and Rejecting Artificial Social Partners in the Uncanny Valley.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
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- Neural encoding of choice during a delayed response task in primate striatum and orbitofrontal cortex.Experimental brain research · 2018Article
- Amygdala activity for the modulation of goal-directed behavior in emotional contexts.PLoS biology · 2018Article
- Free choice shapes normalized value signals in medial orbitofrontal cortex.Nature communications · 2018Article
- In monkeys making value-based decisions, amygdala neurons are sensitive to cue value as distinct from cue salience.Journal of neurophysiology · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The amygdala is a prime valuation structure yet its functions in advanced behaviors are poorly understood. We tested whether individual amygdala neurons encode a critical requirement for goal-directed behavior: the evaluation of progress during sequential choices. As monkeys progressed through choice sequences toward rewards, amygdala neurons showed phasic, gradually increasing responses over successive choice steps. These responses occurred in the absence of external progress cues or motor preplanning. They were often specific to self-defined sequences, typically disappearing during instructed control sequences with similar reward expectation. Their build-up rate reflected prospectively the forthcoming choice sequence, suggesting adaptation to an internal plan. Population decoding demonstrated a high-accuracy progress code. These findings indicate that amygdala neurons evaluate the progress of planned, self-defined behavioral sequences. Such progress signals seem essential for aligning stepwise choices with internal plans. Their presence in amygdala neurons may inform understanding of human conditions with amygdala dysfunction and deregulated reward pursuit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.