Evidence map›Paper›PMID 27731409›Full record

ArticleScientific reports2016

Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaques.

Johanna M U Silvola, Helena Virtanen, Riikka Siitonen, Sanna Hellberg, Heidi Liljenbäck, Olli Metsälä, Mia Ståhle, Tiina Saanijoki, Meeri Käkelä, Harri Hakovirta and 8 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 37 citations in OpenAlex.

  1. Trial
  2. From incidental positron emission uptake toFrontiers in cardiovascular medicine · 2026
    Review
  3. The role of VAP-1 in cardiovascular disease: a review.Frontiers in cardiovascular medicine · 2025
    Review
  4. Review
  5. Article
  6. Vascular adhesion protein-1-targeted PET imaging in autoimmune myocarditis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  7. Review
  8. PET/MR imaging of inflammation in atherosclerosis.Nature biomedical engineering · 2023
    Review
  9. Increased atherosclerotic plaque in AOC3 knock-out in ApoEFrontiers in cardiovascular medicine · 2022
    Article
  10. Positron Emission Tomography in Atherosclerosis Research.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  11. Review
  12. First-in-Humans Study ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

Johanna M U SilvolaTurku PET Centre, University of Turku, FI-20521 Turku, Finland.
Helena VirtanenTurku PET Centre, University of Turku, FI-20521 Turku, Finland.
Riikka SiitonenTurku PET Centre, University of Turku, FI-20521 Turku, Finland.
Sanna HellbergTurku PET Centre, University of Turku, FI-20521 Turku, Finland.
Heidi LiljenbäckTurku PET Centre, University of Turku, FI-20521 Turku, Finland.
Olli MetsäläTurku PET Centre, University of Turku, FI-20521 Turku, Finland.
Mia StåhleTurku PET Centre, University of Turku, FI-20521 Turku, Finland.
Tiina SaanijokiTurku PET Centre, University of Turku, FI-20521 Turku, Finland.
Meeri KäkeläTurku PET Centre, University of Turku, FI-20521 Turku, Finland.
Harri HakovirtaDepartment of Vascular Surgery, Turku University Hospital and University of Turku, FI-20520 Turku, Finland.
Seppo Ylä-HerttualaA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.
Pekka SaukkoDepartment of Pathology and Forensic Medicine, University of Turku, FI-20520 Turku, Finland.
Matti JauhiainenNational Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum, FI-00251 Helsinki, Finland.
Tibor Z VeresMediCity Research Laboratory and Department of Medical Microbiology and Immunology, University of Turku, FI-20520 Turku, Finland.
Sirpa JalkanenMediCity Research Laboratory and Department of Medical Microbiology and Immunology, University of Turku, FI-20520 Turku, Finland.
Juhani KnuutiTurku PET Centre, University of Turku, FI-20521 Turku, Finland.
Antti SarasteTurku PET Centre, University of Turku, FI-20521 Turku, Finland.
Anne RoivainenTurku PET Centre, University of Turku, FI-20521 Turku, Finland.
University of Turku · FITurku PET Centre · FIFinnish Institute for Health and Welfare · FITurku University Hospital · FIUniversity of Eastern Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Given the important role of inflammation and the potential association of the leukocyte trafficking-associated adhesion molecule vascular adhesion protein 1 (VAP-1) with atherosclerosis, this study examined whether functional VAP-1 is expressed in atherosclerotic lesions and, if so, whether it could be targeted by positron emission tomography (PET). First, immunohistochemistry revealed that VAP-1 localized to endothelial cells of intra-plaque neovessels in human carotid endarterectomy samples from patients with recent ischemic symptoms. In low-density lipoprotein receptor-deficient mice expressing only apolipoprotein B100 (LDLR

Indexed as

AdultAmine Oxidase (Copper-Containing)AnimalsAntigens, CDApolipoprotein B-100Carotid StenosisCell Adhesion MoleculesFemaleGallium RadioisotopesHeterocyclic Compounds, 1-RingHumansMaleMiceMice, Inbred C57BLMice, KnockoutMiddle Aged1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidAmine Oxidase (Copper-Containing)Antigens, CDAOC3 protein, humanApolipoprotein B-100Cell Adhesion MoleculesGallium RadioisotopesHeterocyclic Compounds, 1-RingReceptors, LDLsemicarbazide-sensitive amine oxidase-vascular adhesion protein-1, mouseSialic Acid Binding Immunoglobulin-like Lectinssiglec-9 protein, mouse

Identifiers

PMID27731409
PMCPMC5059718
OpenAlexW2547471207

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.