ArticleScientific reports2016
Vagus Nerve Stimulation Alters Phase Synchrony of the Anterior Cingulate Cortex and Facilitates Decision Making in Rats.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Transcutaneous auricular vagus nerve stimulation for anxiety symptoms across fear, trauma, and disease contexts: a narrative review of clinical evidence and mechanisms.European archives of psychiatry and clinical neuroscience · 2026Review
- Non-invasive Vagal Nerve Stimulation as a Potential Treatment for Repetitive Blast Trauma.bioRxiv : the preprint server for biology · 2026Article
- A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action.Comprehensive physiology · 2026Review
- Pairing extinction training with vagus nerve stimulation reduces drug-seeking by altering activity in afferents to the medial prefrontal cortex.Frontiers in neuroscience · 2026Article
- Pairing extinction training with vagus nerve stimulation (VNS) reduces drug-seeking by altering activity in afferents to the medial prefrontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Transcutaneous auricular vagus nerve stimulation alleviates anxiety-like behaviors in mice with post-traumatic stress disorder by regulating glutamatergic neurons in the anterior cingulate cortex.Translational psychiatry · 2025Article
- Vagal Sensory Gut-Brain Pathways That Control Eating-Satiety and Beyond.Comprehensive physiology · 2025Review
- Vibrotactile auricular vagus nerve stimulation alters limbic system connectivity in humans: A pilot study.PloS one · 2025Article
- Vagus Nerve Stimulation (VNS) Modulates Synaptic Plasticity in the Infralimbic Cortex via Trk-B Receptor Activation to Reduce Drug-Seeking in Male Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Vagus nerve stimulation (VNS) modulates synaptic plasticity in the rat infralimbic cortex via Trk-B receptor activation to reduce drug-seeking.bioRxiv : the preprint server for biology · 2024Article
- Stress-induced vagal activity influences anxiety-relevant prefrontal and amygdala neuronal oscillations in male mice.Nature communications · 2024Article
- Astrocytic GPCR signaling in the anterior cingulate cortex modulates decision making in rats.Oxford open neuroscience · 2024Article
- Autism Spectrum Disorder: A Neuro-Immunometabolic Hypothesis of the Developmental Origins.Biology · 2023Article
- Acute Vagus Nerve Stimulation Facilitates Short Term Memory and Cognitive Flexibility in Rats.Brain sciences · 2022Article
- Cortical Responses to Vagus Nerve Stimulation Are Modulated by Brain State in Nonhuman Primates.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Trigeminal neuropathy causes hypomyelination in the anterior cingulate cortex, disrupts the synchrony of neural circuitry, and impairs decision-making in male rats.Journal of neuroscience research · 2021Article
- Suppression of Pain in the Late Phase of Chronic Trigeminal Neuropathic Pain Failed to Rescue the Decision-Making Deficits in Rats.International journal of molecular sciences · 2021Article
- Optogenetic Manipulation of the Vagus Nerve.Advances in experimental medicine and biology · 2021Article
- Associations of Alpha and Beta Interhemispheric EEG Coherences with Indices of Attentional Control and Academic Performance.Behavioural neurology · 2020Article
- Schema-like learning and memory consolidation acting through myelination.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vagus nerve stimulation (VNS) can enhance memory and cognitive functions in both rats and humans. Studies have shown that VNS influenced decision-making in epileptic patients. However, the sites of action involved in the cognitive-enhancement are poorly understood. By employing a conscious rat model equipped with vagus nerve cuff electrode, we assess the role of chronic VNS on decision-making in rat gambling task (RGT). Simultaneous multichannel-recordings offer an ideal setup to test the hypothesis that VNS may induce alterations of in both spike-field-coherence and synchronization of theta oscillations across brain areas in the anterior cingulate cortex (ACC) and basolateral amygdala (BLA). Daily VNS, administered immediately following training sessions of RGT, caused an increase in 'good decision-maker' rats. Neural spikes in the ACC became synchronized with the ongoing theta oscillations of local field potential (LFP) in BLA following VNS. Moreover, cross-correlation analysis revealed synchronization between the ACC and BLA. Our results provide specific evidence that VNS facilitates decision-making and unveils several important roles for VNS in regulating LFP and spike phases, as well as enhancing spike-phase coherence between key brain areas involved in cognitive performance. These data may serve to provide fundamental notions regarding neurophysiological biomarkers for therapeutic VNS in cognitive impairment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.