Evidence map›Paper›PMID 27731333›Full record

ArticleThe Journal of antibiotics2017

New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp. CB01883.

Zhikai Guo, Guohui Pan, Zhengren Xu, Dong Yang, Hindra, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Yanwen Duan and 1 more

Abstract read
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In one paragraph

Article in The Journal of antibiotics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. NewTheScientificWorldJournal · 2025
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Hericioic AcidsJournal of agricultural and food chemistry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhikai GuoDepartment of Chemistry, The Scripps Research Institute, Jupiter, FL, USA.
Guohui PanDepartment of Chemistry, The Scripps Research Institute, Jupiter, FL, USA.
Zhengren XuDepartment of Chemistry, The Scripps Research Institute, Jupiter, FL, USA.
Dong YangDepartment of Chemistry, The Scripps Research Institute, Jupiter, FL, USA.
HindraDepartment of Chemistry, The Scripps Research Institute, Jupiter, FL, USA.
Xiangcheng ZhuXiangya International Academy of Translational Medicine, Central South University, Hunan, China.
Yong HuangXiangya International Academy of Translational Medicine, Central South University, Hunan, China.
Li-Xing ZhaoYunnan Institute of Microbiology, Yunnan University, Yunnan, China.
Yi JiangYunnan Institute of Microbiology, Yunnan University, Yunnan, China.
Yanwen DuanXiangya International Academy of Translational Medicine, Central South University, Hunan, China.
Ben ShenDepartment of Chemistry, The Scripps Research Institute, Jupiter, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Isofuranonaphthoquinones (IFQs) and Isoindolequinones (IIQs) comprise a small family of natural products, with the latter ones are especially uncommon in nature. Here we report the discovery of seven new IFQs, IFQ A-G (1-7), and three new IIQs, IIQ A-C (8-10), along with the known anthraquinone desoxyerythrolaccin (11), from Streptomyces sp. CB01883, expanding the chemical diversity of this family of natural products. The structures of these natural products were established on the basis of their HR-ESI-MS and nuclear magnetic resonance (NMR) spectroscopic data. All compounds were assessed for antibacterial activity, with 11 and 1, 5-7 exhibiting moderate and weak activities, respectively, against several Gram-positive bacteria tested. Bioinformatics analysis of the Streptomyces sp. CB01883 genome revealed the ifq gene cluster that showed identical genetic organization, with high-sequence identity, to the ifn gene cluster recently cloned from Streptomyces sp. RI-77 and confirmed to encode the biosynthesis of two IFQs, JBIR-76 and JBIR-77. Co-isolation of IFQs with IIQs from Streptomyces sp. CB01883 and facile chemical transformation of selected IFQs to IIQs, as exemplified by 1 to 9, together with the finding of the ifq cluster that most likely only encodes IFQ biosynthesis, support the proposal that IIQs may be derived nonenzymatically from IFQs in the presence of an amine.

Indexed as

Anti-Bacterial AgentsBiological ProductsComputational BiologyEscherichia coliFermentationGram-Positive BacteriaIndolequinonesMicrobial Sensitivity TestsMolecular StructureMultigene FamilyNaphthoquinonesNuclear Magnetic Resonance, BiomolecularSpectrometry, Mass, Electrospray IonizationStreptomycesAnti-Bacterial AgentsBiological ProductsIndolequinonesNaphthoquinones

Identifiers

PMID27731333

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.