Evidence map›Paper›PMID 27730819›Full record

Trial reportFuture cardiology2016

A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS.

Konstantin Schwarz, Satnam Singh, Satish Kumar Parasuraman, Maggie Bruce, Lee Shepstone, Martin Feelisch, Magdalena Minnion, Shakil Ahmad, John Horowitz, Dana K Dawson and 1 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Future cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. The unspoken benefit of participation in a clinical trial.Clinical medicine (London, England) · 2021
    Trial
  2. Trial
  3. Nitrite and nitrate chemical biology and signalling.British journal of pharmacology · 2019
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Konstantin SchwarzSchool of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.
Satnam SinghSchool of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.
Satish Kumar ParasuramanSchool of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.
Maggie BruceSchool of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.
Lee ShepstoneNorwich Medical School, University of East Anglia, Bob Champion Research & Education Building James Watson Road, Norwich, NR4 7UQ, UK.
Martin FeelischUniversity of Southampton, Southampton, UK.
Magdalena MinnionUniversity of Southampton, Southampton, UK.
Shakil AhmadAston Medical Research Institute, Aston Medical School, Aston University, Birmingham, B4 7ET, UK.
John HorowitzSchool of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.
Dana K DawsonSchool of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.
Michael P FrenneauxSchool of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.
University of Aberdeen · GBUniversity of East Anglia · GBUniversity of Southampton · GBAston Medical (France) · FRUniversity of Adelaide · AUWorcestershire Royal Hospital · GB

Funding

Medical Research Council G1001340Medical Research Council G1001536
6 · The paper itself

Abstract

In an aging western population, a significant number of patients continue to suffer from angina once all revascularization and optimal medical treatment options are exhausted. Under experimental conditions, oral supplementation with inorganic nitrate was shown to exhibit a blood pressure-lowering effect, and has also been shown to promote angiogenesis, improve endothelial dysfunction and mitochondrial efficiency in skeletal muscle. It is unknown whether similar changes occur in cardiac muscle. In the current study, we investigate whether oral sodium nitrate treatment will improve myocardial ischemia in patients with stable angina.

Indexed as

Administration, OralAgedAngina, StableCross-Over StudiesDouble-Blind MethodExercise TestHumansMyocardial IschemiaNitratesNitratessodium nitrateanginainorganic nitraterandomized controlled trial

Identifiers

PMID27730819
PMCPMC5097453
OpenAlexW2530525990

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.