Evidence map›Paper›PMID 27730767›Full record

ArticleJournal of clinical neurology (Seoul, Korea)2017

Cardiovascular Autonomic Dysfunction in Patients with Drug-Induced Parkinsonism.

Joong Seok Kim, Dong Woo Ryu, Ju Hee Oh, Yang Hyun Lee, Sung Jin Park, Kipyung Jeon, Jong Yun Lee, Seong Hee Ho, Jungmin So, Jin Hee Im and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical neurology (Seoul, Korea), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. VEGF Signaling in Neurological Disorders.International journal of molecular sciences · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Joong Seok KimDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea. neuronet@catholic.ac.kr.
Dong Woo RyuDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Ju Hee OhDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Yang Hyun LeeDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Sung Jin ParkDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kipyung JeonDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jong Yun LeeDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Seong Hee HoDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jungmin SoDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jin Hee ImDepartment of Neurology, Inje University Sanggye Paik Hospital, Seoul, Korea.
Kwang Soo LeeDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Catholic University of Korea · KRInje University Sanggye Paik Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeRecent studies have shown that several nonmotor symptoms differ between Parkinson's disease (PD) and drug-induced parkinsonism (DIP). However, there have been no reports on cardiovascular autonomic function in DIP, and so this study investigated whether cardiovascular autonomic function differs between PD and DIP patients.

methodsThis study consecutively enrolled 20 DIP patients, 99 drug-naïve PD patients, and 25 age-matched healthy controls who underwent head-up tilt-table testing and 24-h ambulatory blood pressure monitoring.

resultsOrthostatic hypotension was more frequent in patients with PD or DIP than in healthy controls. In DIP, orthostatic hypotension was associated with the underlying psychiatric diseases and neuroleptics use, whereas prokinetics were not related to orthostatic hypotension. The supine blood pressure, nighttime blood pressure, and nocturnal blood pressure dipping did not differ significantly between the DIP and control groups. Supine hypertension and nocturnal hypertension were more frequent in PD patients than in controls.

conclusionsThe included DIP patients frequently exhibited orthostatic hypotension that was associated with the underlying diseases as well as the nature of and exposure time to the offending drugs. Clinicians should individualize the manifestations of DIP according to underlying diseases as well as the action mechanism of and exposure time to each offending drug.

Indexed as

cardiovascular autonomic dysfunctiondrug-induced parkinsonismParkinson's disease

Identifiers

PMID27730767
PMCPMC5242160
OpenAlexW2531731918

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.