Trial reportNeuromodulation : journal of the International Neuromodulation Society2017
Subthalamic Nucleus Deep Brain Stimulation Alters Prefrontal Correlates of Emotion Induction.
Trial report in Neuromodulation : journal of the International Neuromodulation Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Affective modulation of the associative-limbic subthalamic nucleus: deep brain stimulation in obsessive-compulsive disorder.Translational psychiatry · 2019Trial
- Subthalamic stimulation shifts brain network dynamics from extensive functional support to motor dominance in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Functional Movement Disorders and Deep Brain Stimulation: A Review.Neurology. Clinical practice · 2025Review
- Deep brain stimulation for Parkinson's Disease: A Review and Future Outlook.Biomedical engineering letters · 2022Review
- Reshaping cortical activity with subthalamic stimulation in Parkinson's disease during finger tapping and gait mapped by near infrared spectroscopy.Journal of applied biomedicine · 2019Article
- Effects of subthalamic nucleus deep brain stimulation on emotional working memory capacity and mood in patients with Parkinson's disease.Neuropsychiatric disease and treatment · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectivesDeep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor symptoms in advanced Parkinson's disease. STN DBS may also affect emotion, possibly by impacting a parallel limbic cortico-striatal circuit. The objective of this study was to investigate changes in prefrontal cortical activity related to DBS during an emotion induction task. MATERIALS AND
methodsWe used near infrared spectroscopy to monitor prefrontal cortex hemodynamic changes during an emotion induction task. Seven DBS patients were tested sequentially in the stimulation-on and stimulation-off states while on dopaminergic medication. Patients watched a series of positive, negative, and neutral videos. The general linear model was used to compare prefrontal oxygenated hemoglobin concentration between DBS states.
resultsDeep brain stimulation was correlated with prefrontal oxygenated hemoglobin changes relative to the stimulation off state in response to both positive and negative videos. These changes were specific to emotional stimuli and were not seen during neutral stimuli.
conclusionsThese results suggest that STN stimulation influences the prefrontal cortical representation of positive and negative emotion induction.
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Registered trials
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