Evidence map›Paper›PMID 27730672›Full record

ArticlePhytotherapy research : PTR2017

Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APC

Takumu Hasebe, Jun Matsukawa, Daina Ringus, Jun Miyoshi, John Hart, Atsushi Kaneko, Masahiro Yamamoto, Toru Kono, Mikihiro Fujiya, Yutaka Kohgo and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Phytotherapy research : PTR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Effect of Daikenchuto On Spontaneous Intestinal Tumors in ApcThe Kobe journal of medical sciences · 2021
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Takumu HasebeDepartment of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, IL, USA.
Jun MatsukawaDepartment of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-9457-3683
Daina RingusDepartment of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, IL, USA.
Jun MiyoshiDepartment of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, IL, USA.
John HartDepartment of Pathology, University of Chicago, Chicago, IL, USA.
Atsushi KanekoTsumura Research Laboratories, Tsumura and Co, Ami, Ibaraki, Japan.
Masahiro YamamotoTsumura Research Laboratories, Tsumura and Co, Ami, Ibaraki, Japan.
Toru KonoCenter for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Hokkaido, Japan.
Mikihiro FujiyaDivision of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
Yutaka KohgoDivision of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
Chong-Zi WangTang Center for Herbal Medicine Research, Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL, USA.
Chun-Su YuanTang Center for Herbal Medicine Research, Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL, USA.
Marc BissonnetteDepartment of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, IL, USA.
Mark W MuschDepartment of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, IL, USA.
Eugene B ChangDepartment of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, IL, USA.
University of Chicago · USAsahikawa Medical University · JPTsumura Research Institute (Japan) · JP

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI MARK W. LINGEN · 1985 to 2026
$122.1M
ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI LIU, CAMBRIAN YANGSHAO · 1990 to 2025
$29.8M
Mutualistic relationship between Hsp25/27 and gut microbes as a major and essential determinant of mucosal healing and microbial fitness following intestinal injuryR01DK047722 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1993 to 2020
$4.3M
Cytoprotective Role of Heat Shock Proteins in IBDR37DK047722 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 2008 to 2017
$3.8M
Roles of ErbB Signaling in Colonic CarcinogenesisR01CA036745 · NCI · UNIVERSITY OF CHICAGO · PI BISSONNETTE, BRUCE MARC · 1985 to 2007
$2.3M
Dietary fat effects on gut microbes, host immune state and experimental colitisR01DK097268 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 2012 to 2016
$2.2M
Roles of EGFR and miR-143/miR-145 in Western diet-promoted colonic tumorigenesisR01CA164124 · NCI · UNIVERSITY OF CHICAGO · PI BISSONNETTE, BRUCE MARC · 2012 to 2016
$1.6M
COLONIC EPITHELIAL CELL PLASMA MEMBRANESR37CA036745 · NCI · UNIVERSITY OF CHICAGO · PI BRASITUS, THOMAS A · 1986 to 1999
–
NCI NIH HHS P30 CA014599NCI NIH HHS R01 CA036745NCI NIH HHS R01 CA164124NCI NIH HHS R37 CA036745NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK047722NIDDK NIH HHS R01 DK097268NIDDK NIH HHS R37 DK047722
6 · The paper itself

Abstract

Chemopreventative properties of traditional medicines and underlying mechanisms of action are incompletely investigated. This study demonstrates that dietary daikenchuto (TU-100), comprised of ginger, ginseng, and Japanese pepper effectively suppresses intestinal tumor development and progression in the azoxymethane (AOM) and APC

Indexed as

AnimalsAzoxymethaneColonic NeoplasmsDisease Models, AnimalMaleMedicine, TraditionalMicePanaxPlant ExtractsZanthoxylumZingiberaceaeAzoxymethanedai-kenchu-toPlant Extractsadenomatous polyposis coliEGF receptorginsengKampoβ-catenin

Identifiers

PMID27730672
PMCPMC5590753
OpenAlexW2554382913

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.