Evidence map›Paper›PMID 27730664›Full record

ArticleCommunity dentistry and oral epidemiology2017

Toward a genetic understanding of dental fear: evidence of heritability.

Cameron L Randall, John R Shaffer, Daniel W McNeil, Richard J Crout, Robert J Weyant, Mary L Marazita

Abstract read
In one paragraph

Article in Community dentistry and oral epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. Facilitating Green Supply Chain in Dental Care through Kansei Healthscape of Positive Emotions.International journal of environmental research and public health · 2019
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  15. Dental fear among transgender individuals - a cross-sectional survey.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cameron L RandallDepartment of Psychology, Eberly College of Arts and Sciences, West Virginia University, Morgantown, WV, USA.
John R ShafferDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Daniel W McNeilCenter for Oral Health Research in Appalachia, Pittsburgh, PA, USA.
Richard J CroutCenter for Oral Health Research in Appalachia, Pittsburgh, PA, USA.
Robert J WeyantCenter for Oral Health Research in Appalachia, Pittsburgh, PA, USA.
Mary L MarazitaCenter for Oral Health Research in Appalachia, Pittsburgh, PA, USA.

Funding

Psychosocial Influences on Rural Children's Oral HealthR01DE014899 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FOXMAN, BETSY, MARAZITA, MARY L. · 2002 to 2020
$39.9M
Research Training Program in the Behavioral and Biomedical SciencesT32GM081741 · NIGMS · WEST VIRGINIA UNIVERSITY · PI BERREBI, ALBERT S, SIMPKINS, JAMES W. · 2008 to 2018
$2.1M
Dental pain sensitivity, fear, and avoidance: Linkages with the MC1R geneF31DE023493 · NIDCR · WEST VIRGINIA UNIVERSITY · PI RANDALL, CAMERON L · 2014 to 2015
$86k
National Institute of Dental and Craniofacial Research F31-DE023493National Institute of Dental and Craniofacial Research R01-DE014899National Institute of General Medical Sciences T32-GM081741NIDCR NIH HHS F31 DE023493NIDCR NIH HHS R01 DE014899NIGMS NIH HHS T32 GM081741
6 · The paper itself

Abstract

objectivesDental fear is a prevalent problem that impacts dental treatment-seeking behavior and thus oral, systemic, and psychological health. Among other important predictors, fear of pain has been shown to be a critical component of dental fear. While learning history (id est, past experience) is known to shape development and maintenance of dental fear and fear of pain, minimal work has addressed genetic etiological variables for these healthcare-related anxieties. With the aim of coming to a more complete conceptualization of dental fear, this study assessed the heritability of dental fear and fear of pain and elucidated the role of genetics in the relation between the constructs.

methodsParticipants (n = 1370; 827 female), aged 11-74 years (M = 29.2, SD = 12.2), in a family-based cohort study completed measures of dental fear and fear of pain. Heritability and genetic correlation were estimated using likelihood-based methods under the variance components framework.

resultsDental fear was 30% heritable (P < 0.001) and fear of pain was 34% heritable (P < 0.001). Notably, there was substantial genetic correlation between dental fear and fear of pain, ρ

conclusionsIt is clear that, in addition to environmental factors, genetic influences are important in the etiology of dental fear and anxiety and should be considered in future studies of fear and anxiety associated with dental treatment and, potentially, interventions aimed at reducing distress that is a barrier to dental treatment utilization.

Indexed as

anxietybehavioral sciencesdental anxietyfeargeneticshereditypain

Identifiers

PMID27730664
PMCPMC5388586

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.