Evidence map›Paper›PMID 27730510›Full record

ArticleMolecular neurobiology2017

Unpredictable Chronic Mild Stress Paradigm Established Effects of Pro- and Anti-inflammatory Cytokine on Neurodegeneration-Linked Depressive States in Hamsters with Brain Endothelial Damages.

Ennio Avolio, Gilda Fazzari, Maria Mele, Raffaella Alò, Merylin Zizza, Wei Jiao, Anna Di Vito, Tullio Barni, Maurizio Mandalà, Marcello Canonaco

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ennio AvolioComparative Neuroanatomy Laboratory of Biology, Ecology and Earth Science Department (DiBEST), University of Calabria, Ponte P. Bucci 4B, 87030, Arcavacata di Rende, Cosenza, Italy. ennioavolio@libero.it.
Gilda FazzariComparative Neuroanatomy Laboratory of Biology, Ecology and Earth Science Department (DiBEST), University of Calabria, Ponte P. Bucci 4B, 87030, Arcavacata di Rende, Cosenza, Italy.
Maria MeleComparative Neuroanatomy Laboratory of Biology, Ecology and Earth Science Department (DiBEST), University of Calabria, Ponte P. Bucci 4B, 87030, Arcavacata di Rende, Cosenza, Italy.
Raffaella AlòComparative Neuroanatomy Laboratory of Biology, Ecology and Earth Science Department (DiBEST), University of Calabria, Ponte P. Bucci 4B, 87030, Arcavacata di Rende, Cosenza, Italy.
Merylin ZizzaComparative Neuroanatomy Laboratory of Biology, Ecology and Earth Science Department (DiBEST), University of Calabria, Ponte P. Bucci 4B, 87030, Arcavacata di Rende, Cosenza, Italy.
Wei JiaoComparative Neuroanatomy Laboratory of Biology, Ecology and Earth Science Department (DiBEST), University of Calabria, Ponte P. Bucci 4B, 87030, Arcavacata di Rende, Cosenza, Italy.
Anna Di VitoDepartment of Clinical and Experimental Medicine, University of Catanzaro "Magna Græcia", Catanzaro, Italy.
Tullio BarniDepartment of Clinical and Experimental Medicine, University of Catanzaro "Magna Græcia", Catanzaro, Italy.
Maurizio MandalàVascular Physiology Lab., Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy.
Marcello CanonacoComparative Neuroanatomy Laboratory of Biology, Ecology and Earth Science Department (DiBEST), University of Calabria, Ponte P. Bucci 4B, 87030, Arcavacata di Rende, Cosenza, Italy.
University of Calabria · ITMagna Graecia University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanisms by which inflammation affects the different emotional moods are only partially known. Previous works have pointed to stress hormones like glucocorticoids plus the vascular factor endothelin-1 as key factors evoking stressful states especially in relation to endothelial dysfunctions. With this work, it was our intention to establish the role of pro- and anti-inflammatory cytokine expression variations towards depression-like behaviors and consequently the development of neurodegeneration events caused by endothelial damages in the hamster (Mesocricetus auratus). Such a rodent, which is considered a valuable animal model to test depression and anxiety states, exhibited a variety of depression-like behaviors including reduction in sucrose consumption, locomotion, and exploration (p < 0.01) following exposure to unpredictable chronic mild stress. Contextually, a tight correlation between unpredictable chronic mild stress-induced depressive states and expression of the pro-inflammatory cytokines was detected as shown by marked expression levels (p < 0.01) of IL-1β and NF-kB in the hippocampus, amygdala, and prefrontal cortex. Even the anti-inflammatory cytokine IL-10 supplied notably significant (p < 0.001) expression levels in the same areas of resilient hamsters. Application of hemodynamic and endothelial functional studies pointed to altered arterial endothelial activities in depressed with respect to resilient animals. Moreover, evident damaged neuronal fields in the above areas of depressed hamsters allowed us to correlate such a behavioral phenomenon to the upregulation of IL-1β and NF-κB. Overall, the differing roles of pro- and anti-inflammatory cytokines on depressive states, especially in view of brain endothelial damages, may provide novel therapeutic measures against mood disorders linked to neurodegenerative diseases.

Indexed as

AnimalsBehavior, AnimalBrainCricetinaeCytokinesDepressionDisease Models, AnimalExploratory BehaviorInflammationMaleMesocricetusNerve DegenerationNeuronsSignal TransductionStress, PsychologicalCytokinesChronic stressful paradigmsDepressionNeurodegenerative eventsNeuroinflammatory cytokinesVascular damages

Identifiers

PMID27730510
OpenAlexW2531619072

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.