ReviewWorld journal of microbiology & biotechnology2016
Production of squalene by microbes: an update.
Review in World journal of microbiology & biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 61 citations in OpenAlex.
- Research progress on metabolic engineering for efficient squalene synthesis in yeast cell factories.Biotechnology letters · 2026Review
- Revealing Functional Traits of Insect Pest Suppressive Rhizobacterial Strains Through Comparative Genomics.Environmental microbiology · 2026Article
- Efficient and green ultrasound-assisted supercritical carbon dioxide extraction of squalene from Amaranthus cruentus grains.Ultrasonics sonochemistry · 2026Article
- Effects of Dietary Squalene Supplementation on the Growth Performance and Disease Resistance of Largemouth Bass.Veterinary sciences · 2026Article
- Production of squalene and fatty acids by Thraustochytrium sp. RT2316-16: effects of dissolved oxygen and the medium composition.Bioresources and bioprocessing · 2025Article
- Optimization of Squalene Production byMolecules (Basel, Switzerland) · 2025Article
- Article
- The Pangenome of Gram-Negative Environmental Bacteria Hides a Promising Biotechnological Potential.Microorganisms · 2023Article
- Bioprocess conditions and regulation factors to optimize squalene production in thraustochytrids.World journal of microbiology & biotechnology · 2023Review
- Preparation and Characterization of a Series of Self-Healable Bio-Based Poly(thiourethane) Vitrimer-like Materials.Polymers · 2023Article
- Media Supplementation with Mannitol and Biotin Enhances Squalene Production ofMolecules (Basel, Switzerland) · 2022Article
- Structural and Molecular Characterization of Squalene Synthase Belonging to the Marine Thraustochytrid SpeciesMarine drugs · 2022Article
- Approaches in the photosynthetic production of sustainable fuels by cyanobacteria using tools of synthetic biology.World journal of microbiology & biotechnology · 2021Review
- Rhodosporidium sp. DR37: a novel strain for production of squalene in optimized cultivation conditions.Biotechnology for biofuels · 2021Article
- Mathematical modeling of population structure in bioreactors seeded with light-controllable microbial stem cells.Mathematical biosciences and engineering : MBE · 2020Article
- Article
- Simultaneous production of DHA and squalene fromBiotechnology for biofuels · 2019Article
- Improving squalene production by enhancing the NADPH/NADPBiotechnology for biofuels · 2019Article
- Squalene Found in Alpine Grassland Soils under a Harsh Environment in the Tibetan Plateau, China.Biomolecules · 2018Article
- Sea Lions Develop Human-like Vernix Caseosa Delivering Branched Fats and Squalene to the GI Tract.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Squalene, a naturally occurring linear triterpene formed via MVA or MEP biosynthetic pathway, is widely distributed in microorganisms, plants and animals. At present, squalene is used extensively in the food, cosmetic and medicine industries because of its antioxidant, antistatic and anti-carcinogenic properties. Increased consumer demand has led to the development of microbial bioprocesses for the commercial production of squalene, in addition to the traditional methods of isolating squalene from the liver oils of deep-sea sharks and plant seed oils. As knowledge of the biosynthetic enzymes and of regulatory mechanisms modulating squalene production increases, opportunities arise for the genetic engineering of squalene production in hosts. In this review, we present the various strategies used up to date to improve and/or engineer squalene production in microbes and analyze yields.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.