ArticleBrain imaging and behavior2017
Abnormalities in brain white matter in adolescents with 22q11.2 deletion syndrome and psychotic symptoms.
Article in Brain imaging and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- EEG power spectral and microstate analyses in the 22q11.2 deletion syndrome: from genetic risk to schizophrenia.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- An exploratory fetal MRI study examining the impact of 22q11.2 microdeletion syndrome on early brain growth.Journal of neurodevelopmental disorders · 2025Article
- Article
- Opposing white matter microstructure abnormalities in 22q11.2 deletion and duplication carriers.Translational psychiatry · 2021Article
- Sex Chromosome Dosage Effects on White Matter Structure in the Human Brain.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Structural control energy of resting-state functional brain states reveals less cost-effective brain dynamics in psychosis vulnerability.Human brain mapping · 2021Article
- Neuroimaging Phenotypes Associated With Risk and Resilience for Psychosis and Autism Spectrum Disorders in 22q11.2 Microdeletion Syndrome.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Review
- White matter correlates of cognitive flexibility in youth with bipolar disorder and typically developing children and adolescents.Psychiatry research. Neuroimaging · 2020Article
- Identifying neurodevelopmental anomalies of white matter microstructure associated with high risk for psychosis in 22q11.2DS.Translational psychiatry · 2020Article
- Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study.Molecular psychiatry · 2020Article
- Abnormalities in white matter tracts in the fronto-striatal-thalamic circuit are associated with verbal performance in 22q11.2DS.Schizophrenia research · 2020Article
- White Matter Microstructure across the Psychosis Spectrum.Trends in neurosciences · 2020Review
- Procyanidin B2 mitigates behavioral impairment and protects myelin integrity in cuprizone-induced schizophrenia in mice.RSC advances · 2018Article
- Frontal dysconnectivity in 22q11.2 deletion syndrome: an atlas-based functional connectivity analysis.Behavioral and brain functions : BBF · 2018Article
- A Mini Review on the Contribution of the Anterior Cingulate Cortex in the Risk of Psychosis in 22q11.2 Deletion Syndrome.Frontiers in psychiatry · 2018Review
- Machine-learning classification of 22q11.2 deletion syndrome: A diffusion tensor imaging study.NeuroImage. Clinical · 2017Article
- Altered structural network architecture is predictive of the presence of psychotic symptoms in patients with 22q11.2 deletion syndrome.NeuroImage. Clinical · 2017Article
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Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
Abstract
background22q11.2 Deletion Syndrome (22q11DS) is considered to be a promising cohort to explore biomarkers of schizophrenia risk based on a 30 % probability of developing schizophrenia in adulthood. In this study, we investigated abnormalities in the microstructure of white matter in adolescents with 22q11DS and their specificity to prodromal symptoms of schizophrenia.
methodsDiffusion Magnetic Resonance Imaging (dMRI) data were acquired from 50 subjects with 22q11DS (9 with and 41 without prodromal psychotic symptoms), and 47 matched healthy controls (mean age 18 +/-2 years). DMRI measures, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were calculated and compared between groups using the Tract Based Spatial Statistics (TBSS) method. Additionally, correlations between dMRI measures and scores on positive symptoms were performed.
resultsReductions in MD, AD and RD (but not FA) were found in the corpus callosum (CC), left and right superior longitudinal fasciculus (SLF), and left and right corona radiata in the entire 22q11DS group. In addition, the 22q11DS subgroup with prodromal symptoms showed reductions in AD and MD, but no changes in RD when compared to the non-prodromal subgroup, in CC, right SLF, right corona radiata and right internal capsule. Finally, AD values in these tracts correlated with the scores on the psychosis subscale.
conclusionMicrostructural abnormalities in brain white matter are present in adolescent subjects with prodromal psychotic symptoms.
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