Evidence map›Paper›PMID 27730401›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2016

Externalized Stents for Pancreatoduodenectomy Provide Value Only in High-Risk Scenarios.

Matthew T McMillan, Brett L Ecker, Stephen W Behrman, Mark P Callery, John D Christein, Jeffrey A Drebin, Douglas L Fraker, Tara S Kent, Major K Lee, Robert E Roses and 2 more

Registry-linked trialAbstract readComparative StudyMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03212196 (Technical Strategies for Pancreatic Fistula Prevention After Pancreaticoduodenectomy in High-risk Pancreatic Remnant), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03212196 nacompletednot on this mapstarted 2017, after this paper: background citation

Technical Strategies for Pancreatic Fistula Prevention After Pancreaticoduodenectomy in High-risk Pancreatic Remnant: a Risk-adjusted Randomized Controlled Trial

TypeinterventionalSponsorAzienda Ospedaliera Universitaria Integrata VeronaRan2017 to 2019Enrolled72ConditionsPancreatic FistulaArmsPancreaticogastrostomy with external drain, Pancreaticojejunostomy with transanastomotic drain
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. How i do it: microscope augmented pancreaticojejunostomy.Langenbeck's archives of surgery · 2023
    Article
  12. Article
  13. Article
  14. Evolving the Paradigm of Early Drain Removal Following Pancreatoduodenectomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019
    Article
  15. Pancreatogastrostomy Vs. Pancreatojejunostomy: a Risk-Stratified Analysis of 5316 Pancreatoduodenectomies.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018
    Article
  16. Recent Advances in Pancreatic Cancer Surgery.Current treatment options in gastroenterology · 2017
    Review
  17. Different types of pancreatico-enteric anastomosis.Translational gastroenterology and hepatology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Matthew T McMillanDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Brett L EckerDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Stephen W BehrmanDepartment of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA.
Mark P CalleryDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
John D ChristeinDepartment of Surgery, University of Alabama School of Medicine, Birmingham, AL, USA.
Jeffrey A DrebinDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Douglas L FrakerDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Tara S KentDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Major K LeeDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Robert E RosesDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Michael H SprysDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Charles M VollmerDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. Charles.Vollmer@uphs.upenn.edu.
University of Pennsylvania · USBeth Israel Deaconess Medical Center · USHarvard University · USUniversity of Alabama at Birmingham · USUniversity of Tennessee Health Science Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence suggests externalized trans-anastomotic stents may be beneficial as a fistula mitigation strategy for pancreatoduodenectomy (PD); however, previous studies have not been rigorously risk-adjusted.

methodsFrom 2001 to 2015, PDs were performed at three institutions, with externalized stents placed at the surgeon's discretion. The Fistula Risk Score (FRS) and the Modified Accordion Severity Grading System were used to analyze occurrence and severity of clinically relevant postoperative pancreatic fistula (CR-POPF) across various risk scenarios.

resultsOf 729 PDs, externalized stents were placed during 129 (17.7 %). Overall, CR-POPFs occurred in 77 (10.6 %) patients. The median FRS of patients who received externalized stents was significantly higher compared with patients who did not (6 vs. 3, p < 0.0001). Patients with negligible, low, or moderate CR-POPF risk (FRS 0-6) did not demonstrate improved outcomes with externalized stents; however, among high-risk patients (FRS 7-10), stents were associated with significantly reduced rates of CR-POPF (14.0 vs. 36.4 %, p = 0.031), severe complications (p = 0.039), and hospital stay (p = 0.014) compared with no stents. The average complication burden of CR-POPF was significantly lower for patients with externalized stents (p = 0.035).

conclusionThis multicenter study, the largest comparative analysis of externalized trans-anastomotic stents versus no stent for PD, demonstrates a risk-stratified benefit to externalized stents.

Indexed as

StentsAgedAnastomosis, SurgicalFemaleHumansLength of StayMaleMiddle AgedPancreatic FistulaPancreaticoduodenectomyPostoperative ComplicationsRisk AdjustmentSeverity of Illness IndexPancreatectomyPancreatic fistulaPancreatoduodenectomyStent

Identifiers

PMID27730401
OpenAlexW2530993007

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.