Evidence map›Paper›PMID 27730320›Full record

ArticleInflammation2017

Activation of the NLRP3 Inflammasome Is Associated with Valosin-Containing Protein Myopathy.

Angèle Nalbandian, Arif A Khan, Ruchi Srivastava, Katrina J Llewellyn, Baichang Tan, Nora Shukr, Yasmin Fazli, Virginia E Kimonis, Lbachir BenMohamed

RetractedOpen access · greenAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
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  15. Article
  16. Review
  17. Inflammasome in ALS Skeletal Muscle:International journal of molecular sciences · 2021
    Article
  18. Article
  19. Anti-inflammatory and Anti-oxidant Activity of HidroxAntioxidants (Basel, Switzerland) · 2020
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Angèle NalbandianLaboratory of Cellular and Molecular Immunology, Gavin Herbert Institute, School of Medicine, University of California Irvine, Irvine, CA, 92697, USA. a.nalbandian@uci.edu.
Arif A KhanLaboratory of Cellular and Molecular Immunology, Gavin Herbert Institute, School of Medicine, University of California Irvine, Irvine, CA, 92697, USA.
Ruchi SrivastavaLaboratory of Cellular and Molecular Immunology, Gavin Herbert Institute, School of Medicine, University of California Irvine, Irvine, CA, 92697, USA.
Katrina J LlewellynDivision of Genetics and Genomics Medicine, Department of Pediatrics, University of California Irvine, Irvine, CA, 92697, USA.
Baichang TanDivision of Genetics and Genomics Medicine, Department of Pediatrics, University of California Irvine, Irvine, CA, 92697, USA.
Nora ShukrLaboratory of Cellular and Molecular Immunology, Gavin Herbert Institute, School of Medicine, University of California Irvine, Irvine, CA, 92697, USA.
Yasmin FazliLaboratory of Cellular and Molecular Immunology, Gavin Herbert Institute, School of Medicine, University of California Irvine, Irvine, CA, 92697, USA.
Virginia E KimonisDivision of Genetics and Genomics Medicine, Department of Pediatrics, University of California Irvine, Irvine, CA, 92697, USA.
Lbachir BenMohamedLaboratory of Cellular and Molecular Immunology, Gavin Herbert Institute, School of Medicine, University of California Irvine, Irvine, CA, 92697, USA. lbenmoha@uci.edu.
University of California, Irvine · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
NCATS NIH HHS UL1 TR001414
6 · The paper itself

Abstract

Aberrant activation of the NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome, triggers a pathogenic inflammatory response in many inherited neurodegenerative disorders. Inflammation has recently been associated with valosin-containing protein (VCP)-associated diseases, caused by missense mutations in the VCP gene. This prompted us to investigate whether NLRP3 inflammasome plays a role in VCP-associated diseases, which classically affects the muscles, bones, and brain. In this report, we demonstrate (i) an elevated activation of the NLRP3 inflammasome in VCP myoblasts, derived from induced pluripotent stem cells (iPSCs) of VCP patients, which was significantly decreased following in vitro treatment with the MCC950, a potent and specific inhibitor of NLRP3 inflammasome; (ii) a significant increase in the expression of NLRP3, caspase 1, IL-1β, and IL-18 in the quadriceps muscles of VCP

Indexed as

Adenosine TriphosphatasesAnimalsCell Cycle ProteinsCells, CulturedDisease Models, AnimalFuransHeterocyclic Compounds, 4 or More RingsHumansIndenesInflammasomesInflammationMacrophagesMiceMuscular DiseasesNLR Family, Pyrin Domain-Containing 3 ProteinQuadriceps MuscleAdenosine TriphosphatasesCell Cycle ProteinsFuransHeterocyclic Compounds, 4 or More RingsIndenesInflammasomesN-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamideNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseSulfonamidesSulfonesValosin Containing ProteinVCP protein, humanVcp protein, mousemacrophagemyopathyNLRP3 inflammasomevalosin-containing protein

Identifiers

PMID27730320
PMCPMC5800525
OpenAlexW2530533922

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.