Evidence map›Paper›PMID 27730288›Full record

ArticlePediatric surgery international2017

Surgical treatment of childhood hepatoblastoma in the Netherlands (1990-2013).

Linde A D Busweiler, Marc H W A Wijnen, Jim C H Wilde, Egbert Sieders, Sheila E J Terwisscha van Scheltinga, L W Ernest van Heurn, Joseph Ziros, Roel Bakx, Hugo A Heij

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Article in Pediatric surgery international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Linde A D BusweilerPediatric Surgical Center of Amsterdam, Emma Children's Hospital-Academic Medical Center and VU Medical Center, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands. l.a.d.busweiler@lumc.nl.
Marc H W A WijnenPediatric Surgical Center of Amsterdam, Emma Children's Hospital-Academic Medical Center and VU Medical Center, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands.
Jim C H WildePediatric Surgical Center of Amsterdam, Emma Children's Hospital-Academic Medical Center and VU Medical Center, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands.
Egbert SiedersDepartment of Surgery, University Medical Center Groningen, Groningen, The Netherlands.
Sheila E J Terwisscha van ScheltingaDepartment of Pediatric Surgery, Sophia Children's Hospital-Erasmus Medical Center, Rotterdam, The Netherlands.
L W Ernest van HeurnDepartment of Pediatric Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.
Joseph ZirosDepartment of Pediatric Oncology, Emma Children's Hospital-Academic Medical Center, Amsterdam, The Netherlands.
Roel BakxPediatric Surgical Center of Amsterdam, Emma Children's Hospital-Academic Medical Center and VU Medical Center, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands.
Hugo A HeijPediatric Surgical Center of Amsterdam, Emma Children's Hospital-Academic Medical Center and VU Medical Center, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands.
Emma Kinderziekenhuis · NLAcademic Medical Center · NLErasmus MC - Sophia Children’s Hospital · NLMaastricht University · NLRadboud University Medical Center · NLUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAchievement of complete surgical resection plays a key role in the successful treatment of children with hepatoblastoma. The aim of this study is to assess the surgical outcomes after partial liver resections for hepatoblastoma, focusing on postoperative complications, resection margins, 30-day mortality, and long-term survival.

methodChart reviews were carried out on all patients treated for hepatoblastoma in the Netherlands between 1990 and 2013.

resultsA total of 103 patients were included, of whom 94 underwent surgery. Partial hepatectomy was performed in 76 patients and 18 patients received a liver transplant as a primary procedure. In 42 of 73 (58 %) patients, one or more complications were reported. In 3 patients, information regarding complications was not available. Hemorrhage necessitating blood transfusion occurred in 33 (45 %) patients and 9 (12 %) patients developed biliary complications, of whom 8 needed one or more additional surgical interventions. Overall, 5-year disease-specific survival was 82, 92 % in the group of patients who underwent partial hepatectomy, and 77 % in the group of patients who underwent liver transplantation.

conclusionsPartial hepatectomy after chemotherapy in children with hepatoblastoma offers good chances of survival. This type of major surgery is associated with a high rate of surgical complications (58 %), which is not detrimental to survival.

Indexed as

BiopsyChild, PreschoolFemaleHepatectomyHepatoblastomaHumansIncidenceInfantInfant, NewbornLiverLiver NeoplasmsLiver TransplantationMaleMargins of ExcisionNetherlandsSurvival RateBiliary complicationsHemorrhageHepatoblastomaPartial hepatectomyPostoperative complications

Identifiers

PMID27730288
OpenAlexW2531731769

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.