Trial reportIntensive care medicine2016
Apnoeic oxygenation via high-flow nasal cannula oxygen combined with non-invasive ventilation preoxygenation for intubation in hypoxaemic patients in the intensive care unit: the single-centre, blinded, randomised controlled OPTINIV trial.
Trial report in Intensive care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03615417 (Effectiveness of High-Flow Nasal Cannula), which is not on this map. Cited by 87 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of High-Flow Nasal Cannula (HFNC) Preoxygenation in Obese Patients Undergoing General Anesthesia: A Randomised Controlled Trial
Who cites it
87 citing papers in PubMed, 10 syntheses or guidelines pooled it, 249 citations in OpenAlex.
- Impact of Interventions on Peri-Intubation Hypoxemia and Hypotension in Critically Ill Patients: Systematic Review and Meta-Analysis.The western journal of emergency medicine · 2025Pooled it
- Effect of high-flow nasal oxygen therapy on perioperative hypoxemia in children: a systematic review and meta-analysis.BMC anesthesiology · 2025Pooled it
- Preoxygenation strategies before intubation in patients with acute hypoxic respiratory failure: a network meta-analysis.Frontiers in medicine · 2025Pooled it
- The comparison of preoxygenation methods before endotracheal intubation: a network meta-analysis of randomized trials.Frontiers in medicine · 2024Pooled it
- Oxygenation during the apnoeic phase preceding intubation in adults in prehospital, emergency department, intensive care and operating theatre environments.The Cochrane database of systematic reviews · 2023Pooled it
- The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline.Intensive care medicine · 2020Guideline
- High-flow nasal cannula therapy as apneic oxygenation during endotracheal intubation in critically ill patients in the intensive care unit: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Preoxygenation before intubation in adult patients with acute hypoxemic respiratory failure: a network meta-analysis of randomized trials.Critical care (London, England) · 2019Pooled it
- A Systematic Review of the High-flow Nasal Cannula for Adult Patients.Critical care (London, England) · 2018Pooled it
- Tracheal intubation in critically ill patients: a comprehensive systematic review of randomized trials.Critical care (London, England) · 2018Pooled it
- Randomized controlled trial to assess the effectiveness of apnoeic oxygenation in adults using a low-flow or high-flow nasal cannula with head side elevation during endotracheal intubation in the emergency department.BMC research notes · 2025Trial
- [Is pre-oxygenation with high-flow nasal oxygen safe? randomized control trial of 56 cases of elderly patients during induction of general anesthesia with endotracheal intubation].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Trial
- Nasal high-flow preoxygenation for endotracheal intubation in the critically ill patient: a randomized clinical trial.Intensive care medicine · 2019Trial
- Trial
- Personalizing Peri-Intubation Oxygenation in Patients at Risk of Acute Hypoxemic Respiratory Failure: A Phenotype-Driven Narrative Review of High-Flow Nasal Oxygen and Non-Invasive Ventilation.Journal of personalized medicine · 2026Review
- Airway management in critically ill patients with obesity.Intensive care medicine · 2026Review
- Retrospective Propensity-Matched Comparison of Noninvasive Positive Pressure Ventilation Versus High-Flow Nasal Cannula on Reintubation Rates in Neurosurgical Intensive Care Patients.Neurocritical care · 2026Article
- Preoxygenation When Standard Approaches Fail: Phenotype-Based Strategies for High-Risk Emergent Intubations.Journal of clinical medicine · 2026Review
- Bridging the Oxygenation Gap: A Dual-Modality Approach in Severe Acute Respiratory Distress Syndrome.Cureus · 2026Article
- High-Flow Nasal Cannula Oxygen Therapy in Perioperative Respiratory Care: Application and Prospects.Journal of multidisciplinary healthcare · 2026Review
27 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHigh-flow nasal cannula oxygen (HFNC) has the potential to provide apnoeic oxygenation. We decided to assess in a proof-of-concept study whether the addition of HFNC to non-invasive ventilation (NIV) could reduce oxygen desaturation during intubation, compared with NIV alone for preoxygenation, in severely hypoxaemic intensive care unit (ICU) patients with respiratory failure.
methodsWe conducted a randomised, controlled, single-centre trial with assessor-blinded outcome assessment in patients admitted to the ICU. Hypoxaemic patients requiring orotracheal intubation for respiratory failure were randomised to receive preoxygenation using HFNC [flow = 60 L/min, fraction of inspired oxygen (FiO
resultsBetween July 2015 and February 2016, we randomly assigned 25 and 24 patients to the intervention and reference groups, respectively. In both groups the main reasons for respiratory failure were pneumonia and ARDS. During the intubation procedure, the lowest SpO
conclusionsA novel strategy for preoxygenation in hypoxaemic patients, adding HFNC for apnoeic oxygenation to NIV prior to orotracheal intubation, may be more effective in reducing the severity of oxygen desaturation than the reference method using NIV alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.