Evidence map›Paper›PMID 27730213›Full record

ArticleScience advances2016

Tunable and label-free virus enrichment for ultrasensitive virus detection using carbon nanotube arrays.

Yin-Ting Yeh, Yi Tang, Aswathy Sebastian, Archi Dasgupta, Nestor Perea-Lopez, Istvan Albert, Huaguang Lu, Mauricio Terrones, Si-Yang Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
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  7. Mechanisms, Techniques and Devices of Airborne Virus Detection: A Review.International journal of environmental research and public health · 2023
    Review
  8. Review
  9. Review
  10. Engineering carbon nanotubes for sensitive viral detection.Trends in analytical chemistry : TRAC · 2022
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Carbon nanotubes in COVID-19: A critical review and prospects.Colloid and interface science communications · 2022
    Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yin-Ting YehMicro and Nano Integrated Biosystem Laboratory, Department of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA.; Penn State Material Research Institute, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0002-1512-9267
Yi TangDepartment of Veterinary and Biomedical Science, Pennsylvania State University, University Park, PA 16802, USA.
Aswathy SebastianDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
Archi DasguptaDepartment of Chemistry, Pennsylvania State University, University Park, PA 16802, USA.
Nestor Perea-LopezDepartment of Physics and Center for 2-Dimensional and Layered Materials, Pennsylvania State University, University Park, PA 16802, USA.
Istvan AlbertDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.; Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.
Huaguang LuDepartment of Veterinary and Biomedical Science, Pennsylvania State University, University Park, PA 16802, USA.
Mauricio TerronesPenn State Material Research Institute, Pennsylvania State University, University Park, PA 16802, USA.; Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA.; Department of Physics and Center for 2-Dimensional and Layered Materials, Pennsylvania State University, University Park, PA 16802, USA.; Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.; Department of Materials Science and Engineering, Pennsylvania State University, University Park, PA 16802, USA.
Si-Yang ZhengMicro and Nano Integrated Biosystem Laboratory, Department of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA.; Penn State Material Research Institute, Pennsylvania State University, University Park, PA 16802, USA.; Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.; Department of Electrical Engineering, Pennsylvania State University, University Park, PA 16802, USA.

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
Penn State Clinical and Translational Science InstituteUL1TR000127 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$17.1M
Integration of Flexible Micro Spring Array and High Throughput Microfluidics forDP2CA174508 · NCI · PENNSYLVANIA STATE UNIVERSITY, THE · PI ZHENG, SIYANG · 2012 to 2012
$2.2M
NCATS NIH HHS UL1 TR000127NCATS NIH HHS UL1 TR002014NCI NIH HHS DP2 CA174508
6 · The paper itself

Abstract

Viral infectious diseases can erupt unpredictably, spread rapidly, and ravage mass populations. Although established methods, such as polymerase chain reaction, virus isolation, and next-generation sequencing have been used to detect viruses, field samples with low virus count pose major challenges in virus surveillance and discovery. We report a unique carbon nanotube size-tunable enrichment microdevice (CNT-STEM) that efficiently enriches and concentrates viruses collected from field samples. The channel sidewall in the microdevice was made by growing arrays of vertically aligned nitrogen-doped multiwalled CNTs, where the intertubular distance between CNTs could be engineered in the range of 17 to 325 nm to accurately match the size of different viruses. The CNT-STEM significantly improves detection limits and virus isolation rates by at least 100 times. Using this device, we successfully identified an emerging avian influenza virus strain [A/duck/PA/02099/2012(H11N9)] and a novel virus strain (IBDV/turkey/PA/00924/14). Our unique method demonstrates the early detection of emerging viruses and the discovery of new viruses directly from field samples, thus creating a universal platform for effectively remediating viral infectious diseases.

Indexed as

AnimalsBiosensing TechniquesInfluenza A virusInfluenza in BirdsNanotubes, CarbonTurkeysNanotubes, Carboncarbon nanotubesenrichmentfield samplesimproved detectioninfluenzaN-dopedNGSPCRsensorVirus

Identifiers

PMID27730213
PMCPMC5055386

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.