ArticleScience advances2016
Combinatorial microfluidic droplet engineering for biomimetic material synthesis.
Article in Science advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Extracellular vesicle-mediated gene editing for the treatment of nonsyndromic progressive hearing loss in adult mice.Science translational medicine · 2025Article
- Myogenic nano-adjuvant for orthopedic-related sarcopenia via mitochondrial homeostasis modulation in macrophage-myosatellite metabolic crosstalk.Journal of nanobiotechnology · 2025Article
- FACS-Sortable Triple Emulsion Picoreactors for Screening Reactions in Biphasic Environments.Advanced materials interfaces · 2025Article
- Biomimetic Materials to Fabricate Artificial Cells.Chemical reviews · 2024Review
- Magneto-Controlled Tubular Liquid Actuators with Pore Engineering for Liquid Transport and Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Selective expansion of target cells using the Enrich TROVO platform.BioTechniques · 2023Article
- Recent Advances on Cell Culture Platforms for In Vitro Drug Screening and Cell Therapies: From Conventional to Microfluidic Strategies.Advanced healthcare materials · 2023Review
- Rapid parallel generation of a fluorescently barcoded drop library from a microtiter plate using the plate-interfacing parallel encapsulation (PIPE) chip.Lab on a chip · 2022Article
- Hydrodynamics of Droplet Sorting in Asymmetric Acute Junctions.Micromachines · 2022Article
- Controlled evaporation-induced phase separation of droplets containing nanogels and salt molecules.RSC advances · 2022Article
- High-efficiency quantitative control of mitochondrial transfer based on droplet microfluidics and its application on muscle regeneration.Science advances · 2022Article
- Light-Fueled Submarine-Like Droplet.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Pico-washing: simultaneous liquid addition and removal for continuous-flow washing of microdroplets.Microsystems & nanoengineering · 2022Article
- Liquid crystal-based open surface microfluidics manipulate liquid mobility and chemical composition on demand.Science advances · 2021Article
- Research Progress of Chitosan-Based Biomimetic Materials.Marine drugs · 2021Review
- Shear-mediated sol-gel transition of regenerated silk allows the formation of Janus-like microgels.Scientific reports · 2021Article
- A Magnetically Actuated Superhydrophobic Ratchet Surface for Droplet Manipulation.Micromachines · 2021Article
- Evolutionary design of optimal surface topographies for biomaterials.Scientific reports · 2020Article
- Monodisperse drops templated by 3D-structured microparticles.Science advances · 2020Article
- Organic Composomes as Supramolecular Aptamers.ACS omega · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although droplet-based systems are used in a wide range of technologies, opportunities for systematically customizing their interface chemistries remain relatively unexplored. This article describes a new microfluidic strategy for rapidly tailoring emulsion droplet compositions and properties. The approach uses a simple platform for screening arrays of droplet-based microfluidic devices and couples this with combinatorial selection of the droplet compositions. Through the application of genetic algorithms over multiple screening rounds, droplets with target properties can be rapidly generated. The potential of this method is demonstrated by creating droplets with enhanced stability, where this is achieved by selecting carrier fluid chemistries that promote titanium dioxide formation at the droplet interfaces. The interface is a mixture of amorphous and crystalline phases, and the resulting composite droplets are biocompatible, supporting in vitro protein expression in their interiors. This general strategy will find widespread application in advancing emulsion properties for use in chemistry, biology, materials, and medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.