Evidence map›Paper›PMID 27730157›Full record

ArticleERJ open research2015

Pulmonary rehabilitation and severe exacerbations of COPD: solution or white elephant?

William D-C Man, Milo A Puhan, Samantha L Harrison, Rachel E Jordan, Jennifer K Quint, Sally J Singh

Open access · goldAbstract read
In one paragraph

Article in ERJ open research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Effectiveness of home-based pulmonary rehabilitation: systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2022
    Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Video Teleheath and Pulmonary Rehabilitation: Need for a Better Understanding.American journal of respiratory and critical care medicine · 2020
    Article
  10. Article
  11. Acute exacerbation of COPD during pulmonary rehabilitation: outcomes and risk prediction.International journal of chronic obstructive pulmonary disease · 2018
    Observational
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 3 countries.

William D-C ManNIHR Respiratory Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, UK.
Milo A PuhanEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
Samantha L HarrisonDepartment of Respiratory Medicine, West Park Healthcare Centre, Toronto, ON, Canada.
Rachel E JordanPublic Health, Epidemiology and Biostatistics, School of Health and Population Sciences, University of Birmingham, Birmingham, UK.
Jennifer K QuintDepartment of Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, London, UK.
Sally J SinghNIHR CLAHRC-EM, Centre for Exercise and Rehabilitation Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK; School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
Imperial College London · GBRoyal Brompton & Harefield NHS Foundation Trust · GBUniversity Hospitals of Leicester NHS Trust · GBUniversity of Birmingham · GBUniversity of Zurich · CHWest Park Healthcare Centre · CA

Funding

Department of Health 10/44/01Department of Health CTF-01-12-04Department of Health DHCS/07/07/009Medical Research Council G0902135
6 · The paper itself

Abstract

Hospitalisations for severe exacerbations of chronic obstructive pulmonary disease are associated with significant physical and psychological consequences including an increase in symptom severity, severe reductions in physical activity, a deleterious effect on skeletal muscle, impaired exercise tolerance/ability to self-care, decline in quality of life, and increased anxiety and depression. As these consequences are potentially amenable to exercise training, there is a clear rationale for pulmonary rehabilitation in the peri/post-exacerbation setting. Although a 2011 Cochrane review was overwhelmingly positive, subsequent trials have shown less benefit and real-life observational studies have revealed poor acceptability. Qualitative studies have demonstrated that the patient experience is a determining factor while the presence of comorbidities may influence referral, adherence and response to pulmonary rehabilitation. Systematic reviews of less supervised interventions, such as self-management, have shown limited benefits in the post-exacerbation setting. The recent update of the Cochrane review of peri-exacerbation pulmonary rehabilitation showed that benefits were associated with the "comprehensive" nature of the intervention (the number of sessions received, the intensity of exercise training and education delivered, and the degree of supervision) but implementation is demanding. The challenge is to develop interventions that are deliverable and acceptable around the time of an acute exacerbation but also deliver the desired clinical impact.

Identifiers

PMID27730157
PMCPMC5005122
OpenAlexW2239711506

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.