ArticleSpringerPlus2016
Cytotoxicity of methanol extracts of
Article in SpringerPlus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 88 citations in OpenAlex.
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- Anti-proliferative effects of a polyherbal formulation on HL-60, HCT-116, and HeLa cell lines: a docking simulation and response surface design-aided study.Frontiers in chemistry · 2025Article
- Cytotoxicity, acute and sub-chronic toxicities of the leaves of Bauhinia thonningii (Schumach.) Milne-Redh. (Caesalpiniaceae).BMC complementary medicine and therapies · 2023Article
- A Review onCancers · 2022Review
- Network pharmacology of triptolide in cancer cells: implications for transcription factor binding.Investigational new drugs · 2021Article
- Therapeutic Role ofBreast cancer (Dove Medical Press) · 2021Article
- Current Progress of Phytomedicine in Glioblastoma Therapy.Current medical science · 2020Review
- Botanicals from the leaves ofHeliyon · 2020Article
- Cytotoxic, Antitumor and Toxicological Profile ofMolecules (Basel, Switzerland) · 2020Article
- Review
- The graviola impact on human astroglioma cells: functional significance of MUDENG.RSC advances · 2019Article
- Emerging therapeutic potential of graviola and its constituents in cancers.Carcinogenesis · 2018Review
- Repurposing of Bromocriptine for Cancer Therapy.Frontiers in pharmacology · 2018Article
- Anticancer Properties of Graviola (Oxidative medicine and cellular longevity · 2018Review
- Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets.Frontiers in pharmacology · 2017Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCancer cells rapidly acquire resistance leading to treatment failures. In the present study, we have evaluated the cytotoxicity of 17 methanol extracts from 11 Cameroonian medicinal plants against the sensitive leukemia CCRF-CEM cells and the best ones were further tested on a panel of 8 other human cancer cell lines, including various MDR phenotypes as well as against the normal AML12 hepatocytes.
methodsThe cytotoxicity of the extracts was determined using a resazurin reduction assay meanwhile flow cytometry was used to measure cell cycle, apoptosis, mitochondrial membrane potential (MMP), and reactive oxygen species.
resultsIn an initial screening using leukemia CCRF-CEM cells, ten extracts from five plants namely
conclusionsResults of the present study suggest that some of the tested plants namely
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.