ArticleIranian journal of pediatrics2016
Urinary Uric Acid/Creatinine Ratio as a Marker of Mortality and Unfavorable Outcome in NICU-Admitted Neonates.
Article in Iranian journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Association of Uric Acid in Serum and Urine with Arterial Stiffness: Hanzhong Adolescent Hypertension Study.Disease markers · 2020Trial
- The Urinary Uric Acid / Cr ratio as a marker of morbidity and mortality of preterm infants: a case-control study.BMC pediatrics · 2021Article
- Association of uric acid in serum and urine with subclinical renal damage: Hanzhong Adolescent Hypertension Study.PloS one · 2019Observational
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5 authors.
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Abstract
backgroundThe survival of neonates who have been admitted to the NICU, especially premature infants with few mortality and morbidity, is the most important attitude.
objectivesWe presumed whether urinary uric acid/creatinine (UUA/Cr) ratio can be a marker of mortality and adverse outcome in neonates which were admitted to the NICU. PATIENTS AND
methodsAll preterm infants admitted to our NICU after birth from March 2014 to April 2015 were enrolled in this prospective cohort study. UUA/Cr was measured during the first day of life. The severity of diseases (indicated by the need for high set-up of mechanical ventilation, complications of prematurity, and duration of stay in the NICU) and neonatal death were considered to be the final unfavorable outcomes. The relationship between the Log-transformation (Ln) urinary uric acid/creatinine ratio and the Apgar score at the first and 5
resultsA total of 362 preterm infants with a mean gestational age of 32.7 (± 3.9) weeks were admitted to the NICU, out of whom 64 (17.6%) had severe disease and 43 (11.8%) died. The mean UUA/Cr ratio was significantly higher in the admitted neonates (3.30 ± 1.95 vs. 1.36 ± 0.42. P = 0.0001). There was a negative correlation between the UUA/Cr ratio and the 1-minute Apgar score (r = -0.17, P = 0.006) and the 5-minute Apgar score (r = -0.19, P = 0.003). The 1-minute Apgar scores were negatively correlated with the outcome (OR = 0.68; P < 0.001) and the duration of stay (β = -.28; P < 0.001). There was no significant correlation between 5-minute Apgar scores and the outcome. There was a significant positive correlation between the UUA/Cr ratio and an unfavorable outcome (OR = 1.24; CI %95: 1.06 to 1.43, P = 0.006) and increasing duration of stay (β = 0.17; P = 0.009).
conclusionsThe urinary uric acid/creatinine ratio can be used as a simple, noninvasive parameter of the severity of disease and mortality in NICU-admitted neonates.
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