ArticleFrontiers in behavioral neuroscience2016
Reward vs. Retaliation-the Role of the Mesocorticolimbic Salience Network in Human Reactive Aggression.
Article in Frontiers in behavioral neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- The analysis of the prefrontal cortex and its facilitator role of violence: conclusions of a systematic review and meta-analysis based on neuroimaging results.Brain imaging and behavior · 2026Pooled it
- Neural networks of aggression: ALE meta-analyses on trait and elicited aggression.Brain structure & function · 2019Pooled it
- A systematic review examining the link between psychopathic personality traits, antisocial behavior, and neural reactivity during reward and loss processing.Personality disorders · 2018Pooled it
- Brain reactivity during aggressive response in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- How far does the moral dilemma go? Neural and autonomic correlates contribute to explain emotional conflict and empathy behavior in Sophie's Choice.Frontiers in psychology · 2026Article
- Phenomenological Approaches to Adolescent Girls' Perceptions of Story- writing-based Design Thinking Focused on Aggression.International journal of school health · 2025Article
- The dark sides of the brain: A systematic review and meta-analysis of functional neuroimaging studies on trait aggressionAggression and violent behavior · 2025Article
- Functional cerebello-cortico-limbic connectivity in aggression: A resting-state 7T fMRI study in healthy volunteers.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Characterizing the role of impulsivity in costly, reactive aggression using a novel paradigm.Behavior research methods · 2024Article
- Biomarkers for Cognitive Control, Response Inhibition, Aggressivity, Impulsivity, and Violence.Advances in neurobiology · 2024Review
- A chemical signal in human female tears lowers aggression in males.PLoS biology · 2023Article
- Sniffing the human body volatile hexadecanal blocks aggression in men but triggers aggression in women.Science advances · 2021Article
- Autism and Reactions to Provocation in a Social and Non-social Context.Journal of autism and developmental disorders · 2020Article
- Habenula-prefrontal resting-state connectivity in reactive aggressive men - A pilot study.Neuropharmacology · 2019Article
- Animal Models of (or for) Aggression Reward, Addiction, and Relapse: Behavior and Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Review
- Nucleus Accumbens Drd1-Expressing Neurons Control Aggression Self-Administration and Aggression Seeking in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Neurocircuitry of aggression and aggression seeking behavior: nose poking into brain circuitry controlling aggression.Current opinion in neurobiology · 2018Review
- Compulsive Addiction-like Aggressive Behavior in Mice.Biological psychiatry · 2017Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
The propensity for reactive aggression (RA) which occurs in response to provocation has been linked to hyperresponsivity of the mesocorticolimbic reward network in healthy adults. Here, we aim to elucidate the role of the mesocorticolimbic network in clinically significant RA for two competing motivated behaviors, reward-seeking vs. retaliation. 18 male participants performed a variant of the Point-Subtraction Aggression Paradigm (PSAP) during functional magnetic resonance imaging (fMRI). We examined whether RA participants compared with non-aggressive controls would choose to obtain a monetary reward over the opportunity to retaliate against a fictitious opponent, who provoked the participant by randomly stealing money from his earnings. Across all fMRI-PSAP runs, RA individuals vs. controls chose to work harder to earn money but not to retaliate. When engaging in such reward-seeking behavior vs. retaliation in a single fMRI-PSAP run, RA individuals exhibited increased activation in the insular-striatal part of the mesocorticolimbic salience network, and decreased precuneus and ventromedial prefrontal cortex activation compared to controls. Enhanced overall reward-seeking behavior along with an up-regulation of the mesocorticolimbic salience network and a down-regulation of the default-mode network in RA individuals indicate that RA individuals are willing to work more for monetary reward than for retaliation when presented with a choice. Our findings may suggest that the use of positive reinforcement might represent an efficacious intervention approach for the potential reduction of retaliatory behavior in clinically significant RA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.