Evidence map›Paper›PMID 27729628›Full record

ArticleClinical and molecular hepatology2016

Immunosuppression status of liver transplant recipients with hepatitis C affects biopsy-proven acute rejection.

Jong Man Kim, Kwang-Woong Lee, Gi-Won Song, Bo-Hyun Jung, Hae Won Lee, Nam-Joon Yi, ChoonHyuck David Kwon, Shin Hwang, Kyung-Suk Suh, Jae-Won Joh and 2 more

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Article in Clinical and molecular hepatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jong Man KimDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine; Seoul, Korea.
Kwang-Woong LeeDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Gi-Won SongDivision of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Bo-Hyun JungDivision of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Hae Won LeeDepartment of Surgery, Seoul National University Boramae Medical Center, Seoul, Korea.
Nam-Joon YiDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
ChoonHyuck David KwonDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine; Seoul, Korea.
Shin HwangDivision of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Kyung-Suk SuhDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Jae-Won JohDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine; Seoul, Korea.
Suk-Koo LeeDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine; Seoul, Korea.
Sung-Gyu LeeDivision of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsThe relationship between patient survival and biopsy-proven acute rejection (BPAR) in liver transplant recipients with hepatitis C remains unclear. The aims of this study were to compare the characteristics of patients with and without BPAR and to identify risk factors for BPAR.

methodsWe retrospectively reviewed the records of 169 HCV-RNA-positive patients who underwent LT at three centers.

resultsBPAR occurred in 39 (23.1%) of the HCV-RNA-positive recipients after LT. The 1-, 3-, and 5-year survival rates were 92.1%, 90.3%, and 88.5%, respectively, in patients without BPAR, and 75.7%, 63.4%, and 58.9% in patients with BPAR (

conclusionThe results of the present study suggest that the immunosuppression status of HCV-RNA-positive LT recipients should be carefully determined in order to prevent BPAR and to improve patient survival.

Indexed as

Liver TransplantationAntibodies, MonoclonalBasiliximabBiopsyCyclosporineDrug Therapy, CombinationGenotypeGraft RejectionHepacivirusHepatitis CHumansImmunosuppressive AgentsPolymerase Chain ReactionRecombinant Fusion ProteinsRecurrenceRetrospective StudiesAntibodies, MonoclonalBasiliximabCyclosporineImmunosuppressive AgentsRecombinant Fusion ProteinsRNA, ViralTacrolimusCalcineurin antagonistsHepatitis C virusImmunosuppressionOutcomeRejectionTacrolimus

Identifiers

PMID27729628
PMCPMC5066384

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.