SynthesisJournal of the Royal Society of Medicine2016
Precursors to suicidality and violence on antidepressants: systematic review of trials in adult healthy volunteers.
Synthesis in Journal of the Royal Society of Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Long-term harms from previous use of selective serotonin reuptake inhibitors: A systematic review.The International journal of risk & safety in medicine · 2019Pooled it
- Cognitive behavioural therapy halves the risk of repeated suicide attempts: systematic review.Journal of the Royal Society of Medicine · 2017Pooled it
- Disparities in the prevalence of suicidal ideation according to oral contraceptive pill use among US women: A cross-sectional study.Health science reports · 2024Article
- Investigation of peripheral inflammatory biomarkers in association with suicide risk in major depressive disorder.Frontiers in psychiatry · 2024Article
- Trace amine-associated receptor 1 agonist reduces aggression in brain serotonin-deficient tryptophan hydroxylase 2 knockout rats.Frontiers in psychiatry · 2024Article
- Prescribed Drugs and Self-Directed Violence: A Descriptive Study in the Spanish Pharmacovigilance Database.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Article
- The Effects of Citalopram and Thalamic Dopamine DPsychiatry journal · 2022Article
- Effects of somatic treatments on suicidal ideation and completed suicides.Brain and behavior · 2021Review
- Epilepsy Associated Depression: An Update on Current Scenario, Suggested Mechanisms, and Opportunities.Neurochemical research · 2021Review
- Psychoactive Medication, Violence, and Variant Alleles for Cytochrome P450 Genes.Journal of personalized medicine · 2021Article
- Antidepressant use and interpersonal violence perpetration: a protocol for a systematic review and meta-analysis.BMJ open · 2021Article
- Presentation of benefits and harms of antidepressants on websites: A cross-sectional study.The International journal of risk & safety in medicine · 2020Article
- Concurrent use of benzodiazepines, antidepressants, and opioid analgesics with zolpidem and risk for suicide: a case-control and case-crossover study.Social psychiatry and psychiatric epidemiology · 2019Article
- Is Sertraline a Good Pharmacological Strategy to Control Anger? Results of a Systematic Review.Behavioral sciences (Basel, Switzerland) · 2019Review
- Antidepressant Use During Acute Inpatient Care Is Associated With an Increased Risk of Psychiatric Rehospitalisation Over a 12-Month Follow-Up After Discharge.Frontiers in psychiatry · 2019Article
- Circadian Pattern of Deaths Due to Suicide in Intoxicated Alcohol-Dependent Individuals.The Journal of clinical psychiatry · 2018Article
- Differential Roles of the Two Raphe Nuclei in Amiable Social Behavior and Aggression - An Optogenetic Study.Frontiers in behavioral neuroscience · 2018Article
- The biggest challenge mankind has ever faced.Journal of the Royal Society of Medicine · 2016Article
- Selective Serotonin Reuptake Inhibitors (SSRIs) and Their Effect on Patient Aggression in Adult Patients in a State Psychiatric Facility: A Retrospective Analysis.Innovations in clinical neuroscienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo quantify the risk of suicidality and violence when selective serotonin and serotonin-norepinephrine reuptake inhibitors are given to adult healthy volunteers with no signs of a mental disorder.
designSystematic review and meta-analysis.
main outcome measureHarms related to suicidality, hostility, activation events, psychotic events and mood disturbances.
settingPublished trials identified by searching PubMed and Embase and clinical study reports obtained from the European and UK drug regulators.
participantsDouble-blind, placebo-controlled trials in adult healthy volunteers that reported on suicidality or violence or precursor events to suicidality or violence.
resultsA total of 5787 publications were screened and 130 trials fulfilled our inclusion criteria. The trials were generally uninformative; 97 trials did not report the randomisation method, 75 trials did not report any discontinuations and 63 trials did not report any adverse events or lack thereof. Eleven of the 130 published trials and two of 29 clinical study reports we received from the regulatory agencies presented data for our meta-analysis. Treatment of adult healthy volunteers with antidepressants doubled their risk of harms related to suicidality and violence, odds ratio 1.85 (95% confidence interval 1.11 to 3.08, p = 0.02, I
conclusionsAntidepressants double the occurrence of events in adult healthy volunteers that can lead to suicide and violence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.