Evidence map›Paper›PMID 27729571›Full record

ArticleJournal of the American Society of Nephrology : JASN2017

Genome-Wide Association of CKD Progression: The Chronic Renal Insufficiency Cohort Study.

Afshin Parsa, Peter A Kanetsky, Rui Xiao, Jayanta Gupta, Nandita Mitra, Sophie Limou, Dawei Xie, Huichun Xu, Amanda Hyre Anderson, Akinlolu Ojo and 23 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 5 pooled it
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 5 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Article
  8. Review
  9. Observational
  10. Obesity-related glomerulopathy: How it happens and future perspectives.Diabetic medicine : a journal of the British Diabetic Association · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 18 institutions in 4 countries.

Afshin ParsaDivision of Nephrology and aparsa@medicine.umaryland.edu.
Peter A KanetskyDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Rui XiaoDepartment of Biostatistics and Epidemiology and.
Jayanta GuptaDepartment of Health Sciences, College of Health Professions and Social Work, Florida Gulf Coast University, Fort Myers, FL.
Nandita MitraDepartment of Biostatistics and Epidemiology and.
Sophie LimouMolecular Genetic Epidemiology Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute and Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, Maryland.
Dawei XieDepartment of Biostatistics and Epidemiology and.
Huichun XuDepartments of Medicine and.
Amanda Hyre AndersonCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania.
Akinlolu OjoDivision of Nephrology, University of Michigan, Ann Arbor, Michigan.
John W KusekDivision of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
Claudia M LoraDepartment of Medicine, Division of Nephrology, University of Illinois at Chicago, Chicago, Illinois.
L Lee HammDepartment of Medicine, Section of Nephrology, Tulane University, New Orleans, Louisiana.
Jiang HeDepartment of Medicine, Section of Nephrology, Tulane University, New Orleans, Louisiana.
Niina SandholmFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Janina JeffDepartment of Medicine, The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine Mount Sinai, New York, New York.
Dominic E RajDepartment of Medicine, The George Washington University School of Medicine, Washington, DC.
Carsten A BögerDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Erwin BottingerDepartment of Medicine, The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine Mount Sinai, New York, New York.
Shabnam SalimiEpidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.
Rulan S ParekhDivision of Nephrology, Department of Pediatrics and Medicine, Hospital for Sick Children, University Health Network and the University of Toronto, Toronto, Ontario, Canada.
Sharon G AdlerDepartment of Medicine, Division of Nephrology and Hypertension, Harbor-University of California, Los Angeles Medical Center, Los Angeles, California.
Carl D LangefeldDepartments of Biostatistical Sciences and.
Donald W BowdenBiochemistry and.
FIND Consortium
Per-Henrik GroopFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Carol ForsblomFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Barry I FreedmanDepartment of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Michael LipkowitzDepartment of Medicine, Georgetown University Medical Center, Washington, DC; and.
Caroline S FoxDivision of Intramural Research, National Heart, Lung and Blood Institute's Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, Massachusetts.
Cheryl A WinklerDepartment of Biostatistics and Epidemiology and.
Harold I FeldmanCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania.
and the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators
Florida Gulf Coast University · USCenter for Cancer Research · USIcahn School of Medicine at Mount Sinai · USLeidos Biomedical Research Inc. (United States)Moffitt Cancer Center · USUniversity of Helsinki · FIUniversity of Pennsylvania · USFolkhälsans Forskningscentrum · FIGeorgetown University · USNational Heart Lung and Blood Institute · USNational Institutes of Health · USPediatric Nephrology of Alabama · USUniversity Health Network · CAUniversity of California, Los Angeles · USUniversity of Illinois Chicago · USUniversity of Maryland, Baltimore · USVeterans Health Administration · USWake Forest University · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Scientific and Data Coordinating Center(SDCC) for the P*U01DK060990 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI FELDMAN, HAROLD I · 2001 to 2017
$50.1M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Institutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9M
WORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KOCH, KENNETH L · 1992 to 2010
$35.2M
Zonulin Antibodies in Intestinal Permeabilitiy in IDDMM01RR016500 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI ONUKWUGHA, EBERECHUKWU · 2002 to 2009
$20.2M
Study of the Care and Outcomes of REnal InsufficiencyU01DK060902 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI GO, ALAN S · 2001 to 2025
$19.5M
Limited Competition for the Continuation of the Chronic Renal Insufficiency CohorU01DK061021 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI RAHMAN, MAHBOOB · 2001 to 2025
$17.3M
Prospective Renal Insufficiency Cohort Evaluation:PRICEU01DK060984 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI COHEN, DEBBIE L · 2001 to 2025
$17.0M
Prospective Cohort Study of Chronic Renal InsufficiencyU01DK061028 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAO, PANDURANGA S · 2001 to 2025
$16.9M
Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Hopkins Clinical CenterU01DK061022 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI APPEL, LAWRENCE JOHN · 2001 to 2025
$15.7M
NCATS NIH HHS UL1 TR000003NCATS NIH HHS UL1 TR000424NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR000439NCRR NIH HHS M01 RR007122NCRR NIH HHS M01 RR016500NCRR NIH HHS UL1 RR024131NCRR NIH HHS UL1 RR029879NIA NIH HHS T32 AG000262NIDDK NIH HHS F31 DK072550NIDDK NIH HHS K01 DK092353NIDDK NIH HHS R01 DK066358NIDDK NIH HHS R01 DK139225NIDDK NIH HHS U01 DK060902NIDDK NIH HHS U01 DK060963NIDDK NIH HHS U01 DK060980NIDDK NIH HHS U01 DK060984NIDDK NIH HHS U01 DK060990NIDDK NIH HHS U01 DK061021NIDDK NIH HHS U01 DK061022NIDDK NIH HHS U01 DK061028NIGMS NIH HHS P30 GM103337
6 · The paper itself

Abstract

The rate of decline of renal function varies significantly among individuals with CKD. To understand better the contribution of genetics to CKD progression, we performed a genome-wide association study among participants in the Chronic Renal Insufficiency Cohort Study. Our outcome of interest was CKD progression measured as change in eGFR over time among 1331 blacks and 1476 whites with CKD. We stratified all analyses by race and subsequently, diabetes status. Single-nucleotide polymorphisms (SNPs) that surpassed a significance threshold of

Indexed as

Disease ProgressionGenome-Wide Association StudyBlack or African AmericanBlack PeopleCohort StudiesFemaleHumansMaleMiddle AgedPolymorphism, Single NucleotideRenal Insufficiency, ChronicWhite Peoplechronic kidney diseasehuman geneticspolymorphismsprogression of chronic renal failure

Identifiers

PMID27729571
PMCPMC5328149
OpenAlexW2529940632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.